Asenapine Maleate

Asenapine Maleate Structure
Asenapine Maleate structure
Common Name Asenapine Maleate
CAS Number 85650-56-2 Molecular Weight 401.84000
Density N/A Boiling Point 357.9ºC at 760 mmHg
Molecular Formula C21H20ClNO5 Melting Point 141-145°
MSDS Chinese USA Flash Point 170.2ºC
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger

Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.

J. Neurosci. 35 , 9580-94, (2015)

Due to its distinct pharmacological profile and lower incidence of adverse events compared with other opioids, buprenorphine is considered a safe option for pain and substitution therapy. However, despite its wide clinical use, little is known about the synap...

Asenapine maleate in situ forming biodegradable implant: an approach to enhance bioavailability.

Int. J. Pharm. 477(1-2) , 64-72, (2014)

Biodegradable injectable in-situ forming implants (ISFI) correspond to an alternative parenteral depot system to microspheres and surgical implants. Objective of present work was to formulate and evaluate long acting implant of asenapine maleate (ASM) using P...

Asenapine maleate: a new drug for the treatment of schizophrenia and bipolar mania.

Drugs Today (Barc) 45 , 865-76, (2009)

Schizophrenia and bipolar disorder are serious neuropsychiatric disorders with substantial health risks for patients that result in major socioeconomic burdens on society. Current therapeutic agents fail to adequately address patient needs in terms of efficac...

Fluoxetine impairs GABAergic signaling in hippocampal slices from neonatal rats.

Front. Cell. Neurosci. 7 , 63, (2013)

Fluoxetine (Prozac), an antidepressant known to selectively inhibit serotonin reuptake, is widely used to treat mood disorders in women suffering from depression during pregnancy and postpartum period. Several lines of evidence suggest that this drug, which c...