Etodolac
Etodolac structure
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Common Name | Etodolac | ||
|---|---|---|---|---|
| CAS Number | 41340-25-4 | Molecular Weight | 287.353 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 507.9±45.0 °C at 760 mmHg | |
| Molecular Formula | C17H21NO3 | Melting Point | 145-1480C | |
| MSDS | Chinese USA | Flash Point | 261.0±28.7 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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A new analytical method to determine non-steroidal anti-inflammatory drugs in surface water using in situ derivatization combined with ultrasound-assisted emulsification microextraction followed by gas chromatography-mass spectrometry.
Talanta 129 , 552-9, (2014) Because of the high stability and potential toxic effects of non-steroidal anti-inflammatory drugs (NSAIDs), it is important to closely monitor their concentrations in the environment using a sensitive analytical method. In this study, a simple, rapid, effici... |
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Risk of peptic ulcer bleeding associated with Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs, low-dose aspirin, and antihypertensive drugs: a case-control study.
J. Gastroenterol. Hepatol. 30(2) , 292-8, (2015) The associations between antithrombotic or antihypertensive drugs and peptic ulcer bleeding (PUB) remain unknown, particularly in Asia, where Helicobacter pylori infection is prevalent. This study aims to evaluate the risks of PUB from antithrombotic drugs, a... |
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A method for rapid screening of interactions of pharmacologically active compounds with albumin.
Anal. Chim. Acta 855 , 51-9, (2014) We determine the association constants for ligand-protein complex formation using the flow injection method. We carry out the measurements at high flow rates (F=1 mL min(-1)) of a carrier phase. Therefore, determination of the association constant takes only ... |
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Celecoxib exerts antitumor effects in canine mammary tumor cells via COX‑2‑independent mechanisms.
Int. J. Oncol. 46(3) , 1393-404, (2015) Celecoxib plays antitumor roles via multiple mechanisms in a variety of human cancers. The aim of this study was to clarify the mechanism of action of celecoxib in canine mammary tumors. We examined the antitumor effects of celecoxib in AZACB canine mammary t... |
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Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 mice.
Drug Metab. Dispos. 42(7) , 1146-52, (2014) UDP-glucuronosyltransferases (UGTs) are phase II drug-metabolizing enzymes that catalyze glucuronidation of various drugs. Although experimental rodents are used in preclinical studies to predict glucuronidation and toxicity of drugs in humans, species differ... |
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Etodolac blocks the allyl isothiocyanate-induced response in mouse sensory neurons by selective TRPA1 activation.
Pharmacology 90(1-2) , 47-54, (2012) The excitability of nociceptors is modulated by the transient receptor potential cation channel, ankyrin subfamily, member 1 (TRPA1). We have previously reported that etodolac, a nonsteroidal anti-inflammatory drug, attenuates mechanical allodynia in a mouse ... |
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Targeted screen for human UDP-glucuronosyltransferases inhibitors and the evaluation of potential drug-drug interactions with zafirlukast.
Drug Metab. Dispos. 43 , 812-8, (2015) Inhibition of drug metabolizing enzymes is a major mechanism in drug-drug interactions (DDIs). A number of cases of DDIs via inhibition of UDP-glucuronosyltranseferases (UGTs) have been reported, although the changes in pharmacokinetics are relatively small i... |
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Renal effects of carprofen and etodolac in euvolemic and volume-depleted dogs.
Am. J. Vet. Res. 73(9) , 1485-90, (2012) To determine the effects of carprofen and etodolac on renal function in euvolemic dogs and dogs with extracellular fluid volume depletion induced via administration of furosemide.12 female Beagles.Dogs received a placebo, furosemide, carprofen, etodolac, furo... |
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Evaluating the effects of diclofenac sodium and etodolac on renal hemodynamics with contrast-enhanced ultrasonography: a pilot study.
Eur. J. Clin. Pharmacol. 69(2) , 161-5, (2013) Contrast-enhanced ultrasonography (CEUS) is a novel approach used for measuring organ perfusion changes. Studies using CEUS to assess the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on renal blood flow (RBF) have not yet been conducted. We aimed... |
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Assessment of the efficacy of pamidronate in ankylosing spondylitis: an open prospective trial.
Singapore Med. J. 51(11) , 883-7, (2010) Bisphosphonates have anti-inflammatory properties in arthritic conditions. This study was conducted to assess the therapeutic potential of intravenous pamidronate in nonsteroidal anti-inflammatory drug (NSAID) refractory/intolerant cases of ankylosing spondyl... |