4,4'-Dihydroxybenzophenone
4,4'-Dihydroxybenzophenone structure
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Common Name | 4,4'-Dihydroxybenzophenone | ||
|---|---|---|---|---|
| CAS Number | 611-99-4 | Molecular Weight | 214.22 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 444.8±30.0 °C at 760 mmHg | |
| Molecular Formula | C13H10O3 | Melting Point | 213-215 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 237.0±21.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.
J. Med. Chem. 48 , 5666-74, (2005) We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular dynamics simulations, and linear-interaction energy analysis... |
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Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.
Antimicrob. Agents Chemother. 51 , 3915-23, (2007) Sterol 14alpha-demethylase (CYP51), a major checkpoint in membrane sterol biosynthesis, is a key target for fungal antibiotic therapy. We sought small organic molecules for lead candidate CYP51 inhibitors. The changes in CYP51 spectral properties following li... |
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Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues.
Bioorg. Med. Chem. 15 , 2177-86, (2007) We recently reported that 3,3-dimethyl-3H-benzofuro[3,2,f][1]-benzopyran and its hydrogenated analogue are selective in vitro inhibitors of mycobacterial growth. However, their lack of in vivo activity on a murine model of Mycobacterium tuberculosis infection... |
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Discovery of ligands for a novel target, the human telomerase RNA, based on flexible-target virtual screening and NMR.
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