Glimepiride
Glimepiride structure
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Common Name | Glimepiride | ||
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| CAS Number | 93479-97-1 | Molecular Weight | 490.616 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 677.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C24H34N4O5S | Melting Point | 212.2-214.5 °C | |
| MSDS | Chinese USA | Flash Point | 363.2±34.3 °C | |
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Drug-drug interaction of losartan and glimepiride metabolism by recombinant microsome CYP2C9*1, 2C9*3, 2C9*13, and 2C9*16 in vitro.
Int. J. Clin. Pharmacol. Ther. 52(9) , 732-8, (2014) Co-administration of anti-hypertension and anti-diabetic drugs is common in clinical settings.In this study, we characterized the drug-drug interactions of losartan (LOS) and glimepiride (GLP) using recombinant cytochrome P450 (CYP) 2C9 enzymes (CYP2C9*1, CYP... |
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Role of wetland organic matters as photosensitizer for degradation of micropollutants and metabolites.
J. Hazard. Mater. 276 , 1-9, (2014) Overall photodegradation of pharmaceuticals, personal care products (PPCPs) and pharmaceutical metabolites were investigated in order to evaluate their photochemical fate in aquatic environments in various natural organic matter (NOM) enriched solutions. Test... |
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Analysis of multi-site drug-protein interactions by high-performance affinity chromatography: Binding by glimepiride to normal or glycated human serum albumin.
J. Chromatogr. A. 1408 , 133-44, (2015) High-performance affinity chromatography (HPAC) was used in a variety of formats to examine multi-site interactions between glimepiride, a third-generation sulfonylurea drug, and normal or in vitro glycated forms of the transport protein human serum albumin (... |
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Optimization of self-nanoemulsifying systems for the enhancement of in vivo hypoglycemic efficacy of glimepiride transdermal patches.
Expert Opin. Drug Deliv. 11(7) , 1005-13, (2014) To optimize and use of glimepiride (GMD)-loaded self-nanoemulsifying delivery systems (SNEDs) for the preparation of transdermal patches.Mixture design was utilized to optimize GMD-loaded SNEDs in acidic and aqueous pH media. Optimized GMD-loaded SNEDs were u... |
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Eudragit-based nanosuspension of poorly water-soluble drug: formulation and in vitro-in vivo evaluation.
AAPS PharmSciTech 13(4) , 1031-44, (2012) The present study was performed to investigate potential of Eudragit RLPO-based nanosuspension of glimepiride (Biopharmaceutical Classification System class II drug), for the improvement of its solubility and overall therapeutic efficacy, suitable for peroral... |
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Hydroalcohol extract of Trigonella foenum-graecum seed attenuates markers of inflammation and oxidative stress while improving exocrine function in diabetic rats.
Pharm. Biol. 53(2) , 201-11, (2015) The herb fenugreek, Trigonella foenum-graecum Linn (Fabaceae), seeds have been traditionally used in the treatment of diabetes but its effect on oxidative stress and pro-inflammatory cytokines in the improvement of exocrine function of diabetes has not been s... |
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Optical control of insulin release using a photoswitchable sulfonylurea.
Nat. Commun. 5 , 5116, (2014) Sulfonylureas are widely prescribed for the treatment of type 2 diabetes mellitus (T2DM). Through their actions on ATP-sensitive potassium (KATP) channels, sulfonylureas boost insulin release from the pancreatic beta cell mass to restore glucose homeostasis. ... |
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Actions of KMUP-1, a xanthine and piperazine derivative, on voltage-gated Na(+) and Ca(2+) -activated K(+) currents in GH3 pituitary tumour cells.
Br. J. Pharmacol. 172 , 5110-22, (2015) 7-[2-[4-(2-Chlorophenyl)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) is a xanthine-based derivative. It has soluble GC activation and K(+) -channel opening activity. Effects of this compound on ion currents in pituitary GH3 cells were investigated in this... |
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Synergistic Potentials of Coffee on Injured Pancreatic Islets and Insulin Action via KATP Channel Blocking in Zebrafish.
J. Agric. Food Chem. 63 , 5612-21, (2015) Pancreatic islets (PIs) are damaged under diabetic conditions, resulting in decreased PI size. This study examined the regenerative effects of coffee and its components (caffeine, CFI; trigonelline, TRG; chlorogenic acid, CGA) on zebrafish larval PIs and β-ce... |
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CYP2C metabolism of oral antidiabetic drugs--impact on pharmacokinetics, drug interactions and pharmacogenetic aspects.
Expert Opin. Drug Metab. Toxicol. 8(12) , 1549-63, (2012) The cytochrome P4502C enzymes account for the metabolism of approximately 20% of therapeutic drugs including certain oral antidiabetic drugs (OADs).This review focuses on the effect of CYP2C enzymes on metabolism of sulphonylureas (SUs), meglitinides, and thi... |