2-Methoxy-4-nitrobenzenesulfonyl chloride

2-Methoxy-4-nitrobenzenesulfonyl chloride Structure
2-Methoxy-4-nitrobenzenesulfonyl chloride structure
Common Name 2-Methoxy-4-nitrobenzenesulfonyl chloride
CAS Number 21320-91-2 Molecular Weight 251.644
Density 1.6±0.1 g/cm3 Boiling Point 406.6±35.0 °C at 760 mmHg
Molecular Formula C7H6ClNO5S Melting Point 90-95 °C(lit.)
MSDS Chinese USA Flash Point 199.7±25.9 °C
Symbol GHS05
GHS05
Signal Word Danger

Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors.

Bioorg. Med. Chem. 18(15) , 5576-92, (2010)

Screening of the NCI Diversity Set-1 identified PI-083 (NSC-45382) a proteasome inhibitor selective for cancer over normal cells. Focused libraries of novel compounds based on PI-083 chloronaphthoquinone and sulfonamide moieties were synthesized to gain a bet...