(Tyr4)-Bombesin
(Tyr4)-Bombesin structure
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Common Name | (Tyr4)-Bombesin | ||
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| CAS Number | 67338-70-9 | Molecular Weight | 1669.864 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C74H108N24O19S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Bombesin receptors in distinct tissue compartments of human pancreatic diseases.
Lab. Invest. 80 , 1807-1817, (2000) Overexpression of receptors for regulatory peptides in various human diseases is reportedly of clinical interest. Among these peptides, bombesin and gastrin-releasing peptide (GRP) have been shown to play a physiological and pathophysiological role in pancrea... |
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Modulation of bombesin-induced phosphatidylinositol hydrolysis in a small-cell lung-cancer cell line.
Biochem. J. 255 , 403-410, (1988) Bombesin is an amphibian tetradecapeptide whose mammalian homologue, gastrin-releasing peptide (GRP), is produced by many small-cell lung-cancer (SCLC) cells, and which can function in an autocrine growth-promoting manner in SCLC. Studies reported here show t... |
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Investigation of molecular structure of bombesin and its modified analogues nonadsorbed and adsorbed on electrochemically roughened silver surface.
Biopolymers 89 , 506-521, (2008) This work describes the molecular structure of bombesin (BN) and its analogs on the basis of the absorption infrared and Raman results described below. In these analogues is replaced one ([D-Phe12]BN, [Tyr4]BN, and [Lys3]BN) or two ([Tyr4,D-Phe12]BN, [D-Phe12... |
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Mechanism of [Tyr4]bombesin-induced desensitization in dispersed acini from guinea pig pancreas.
J. Biol. Chem. 257(20) , 12024-9, (1982)
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Identification of the bombesin receptor on murine and human cells by cross-linking experiments.
J. Biol. Chem. 262(23) , 11215-20, (1987) The bombesin receptor present on the surface of murine and human cells was identified using 125I-labeled gastrin-releasing peptide as a probe, the cross-linking agent disuccinimidyl suberate, and sodium dodecyl sulfate gels. A clone of NIH-3T3 cells which pos... |
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High affinity receptors for bombesin/GRP-like peptides on human small cell lung cancer.
Life Sci. 37(2) , 105-13, (1985) The binding of a radiolabeled bombesin analogue to human small cell lung cancer (SCLC) cell lines was investigated. (125I-Tyr4)bombesin bound with high affinity (Kd = 0.5 nM) to a single class of sites (2,000/cell) using SCLC line NCI-H446. Binding was revers... |
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Bombesin-related peptides induce calcium mobilization in a subset of human small cell lung cancer cell lines.
J. Biol. Chem. 262(34) , 16456-60, (1987) To examine the biochemical basis for growth factor-induced responses in human lung cancer cells, we used the quin2 technique to study the effect of the amphibian peptide bombesin and its congeners including mammalian gastrin-releasing peptide (GRP) on the int... |
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High-affinity binding sites for gastrin-releasing peptide on human colorectal cancer tissue but not uninvolved mucosa.
Br. J. Cancer 71(5) , 1087-9, (1995) Human colorectal cancer tissue and matched uninvolved mucosa from 21 patients were examined by radioligand displacement for the presence of binding sites for bombesin-like peptides. Five cancers, but no uninvolved mucosa, expressed high-affinity, low-capacity... |
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ATP induces two cholecystokinin binding affinity states in permeabilized rat pancreatic acini.
Am. J. Physiol. 263(1 Pt 1) , G44-51, (1992) The influence of adenine and guanine nucleotides on cholecystokinin (CCK) receptor binding was examined in streptolysin O-permeabilized rat pancreatic acini. Specific binding of tracer to intact acini was 12.1 +/- 0.4% per milligram protein, while permeabiliz... |
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Bombesin receptors in a human duodenal tumor cell line: binding properties and function.
Cancer Res. 54(3) , 818-24, (1994) The bombesin family of peptides elicit numerous biological responses in the gut, including stimulation of cell proliferation, and have been implicated as growth factors in a variety of gastrointestinal tumors. Even though these peptides and their receptors ar... |