BPTES
BPTES structure
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Common Name | BPTES | ||
|---|---|---|---|---|
| CAS Number | 314045-39-1 | Molecular Weight | 524.681 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C24H24N6O2S3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis.
PLoS Genet. 12 , e1005931, (2016) Cancer cells often rely on glycolysis to obtain energy and support anabolic growth. Several studies showed that glycolytic cells are susceptible to cell death when subjected to low glucose availability or to lack of glucose. However, some cancer cells, includ... |
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Increased glutamine catabolism mediates bone anabolism in response to WNT signaling.
J. Clin. Invest. 125(2) , 551-62, (2015) WNT signaling stimulates bone formation by increasing both the number of osteoblasts and their protein-synthesis activity. It is not clear how WNT augments the capacity of osteoblast progenitors to meet the increased energetic and synthetic needs associated w... |
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Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.
J. Clin. Invest. 125 , 2293-306, (2015) Glutaminase (GLS), which converts glutamine to glutamate, plays a key role in cancer cell metabolism, growth, and proliferation. GLS is being explored as a cancer therapeutic target, but whether GLS inhibitors affect cancer cell-autonomous growth or the host ... |
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Glutamine Regulates Cardiac Progenitor Cell Metabolism and Proliferation.
Stem Cells 33 , 2613-27, (2015) Autologous transplantation of cardiac progenitor cells (CPCs) alleviates myocardial dysfunction in the damaged heart; however, the mechanisms that contribute to their reparative qualities remain poorly understood. In this study, we examined CPC metabolism to ... |
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Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype.
Oncotarget 6 , 12279-96, (2015) Metabolic flexibility might be particularly constrained in tumors bearing mutations in isocitrate dehydrogenase 1 (IDH1) leading to the production of the oncometabolite 2-hydroxygluratate (2HG). To test the hypothesis that IDH1 mutations could generate metabo... |
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Targeting glutamine metabolism in myeloproliferative neoplasms.
Blood Cells Mol. Dis. 55 , 241-7, (2015) JAK2(V617F) mutation can be detected in the majority of myeloproliferative neoplasm (MPN) patients. The JAK2 inhibitor Ruxolitinib is the first FDA-approved treatment for MPNs. However, its use is limited by various dose related toxicities. Here, we studied t... |
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Elevated expression of glutaminase confers glucose utilization via glutaminolysis in prostate cancer.
Biochem. Biophys. Res. Commun. 456(1) , 452-8, (2015) Cancer cells reprogram their metabolism towards aerobic glycolysis and elevated glutaminolysis, which contributes to the aggressive phenotype. Understanding how these metabolic pathways are regulated may provide critical targets for therapeutic intervention. ... |
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Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion.
Nat. Commun. 5 , 4900, (2014) The non-essential amino acid, glutamine, exerts pleiotropic effects on cell metabolism, signalling and stress resistance. Here we demonstrate that short-term glutamine restriction triggers an endoplasmic reticulum (ER) stress response that leads to production... |
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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.
Nature 496(7443) , 101-5, (2013) Cancer cells have metabolic dependencies that distinguish them from their normal counterparts. Among these dependencies is an increased use of the amino acid glutamine to fuel anabolic processes. Indeed, the spectrum of glutamine-dependent tumours and the mec... |
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SIRT5 regulation of ammonia-induced autophagy and mitophagy.
Autophagy 11(2) , 253-70, (2015) In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle. However, while SIRT5 is ubiquitously expressed, urea cycle and CPS1 are only present in the liver and, to a minor extent, in the... |