2,5-Pyridinedicarboxylic acid
2,5-Pyridinedicarboxylic acid structure
|
Common Name | 2,5-Pyridinedicarboxylic acid | ||
|---|---|---|---|---|
| CAS Number | 100-26-5 | Molecular Weight | 167.12 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 441.1±30.0 °C at 760 mmHg | |
| Molecular Formula | C7H5NO4 | Melting Point | 242-247 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 220.5±24.6 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
J. Med. Chem. 54 , 591-602, (2011) Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced hit rates ranging from 29% to 43% for five matrix metallop... |
|
|
Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila.
Antimicrob. Agents Chemother. 51 , 2136-42, (2007) Various inhibitors of metallo-beta-lactamases have been reported; however, none are effective for all subgroups. Those that have been found to inhibit the enzymes of subclass B2 (catalytically active with one zinc) either contain a thiol (and show less inhibi... |
|
|
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
J. Med. Chem. 51 , 7053-6, (2008) The dynamic methylation of histone lysyl residues plays an important role in biology by regulating transcription, maintaining genomic integrity, and by contributing to epigenetic effects. Here we describe a variety of inhibitor scaffolds that inhibit the huma... |