Pirfenidone
Pirfenidone structure
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Common Name | Pirfenidone | ||
|---|---|---|---|---|
| CAS Number | 53179-13-8 | Molecular Weight | 185.222 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 329.1±15.0 °C at 760 mmHg | |
| Molecular Formula | C12H11NO | Melting Point | 96-97ºC | |
| MSDS | Chinese USA | Flash Point | 152.7±11.6 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Lung fibrosis: drug screening and disease biomarker identification with a lung slice culture model and subtracted cDNA Library.
Altern. Lab. Anim. 42(4) , 235-43, (2014) Pulmonary fibrosis is a progressive and irreversible disorder with no appropriate cure. A practical and effective experimental model that recapitulates the disease will greatly benefit the research community and, ultimately, patients. In this study, we tested... |
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A novel genomic signature with translational significance for human idiopathic pulmonary fibrosis.
Am. J. Respir. Cell. Mol. Biol. 52(2) , 217-31, (2015) The bleomycin-induced rodent lung fibrosis model is commonly used to study mechanisms of lung fibrosis and to test potential therapeutic interventions, despite the well recognized dissimilarities to human idiopathic pulmonary fibrosis (IPF). Therefore, in thi... |
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Local delivery of biodegradable pirfenidone nanoparticles ameliorates bleomycin-induced pulmonary fibrosis in mice.
Nanotechnology 23(50) , 505101, (2012) Our purpose was to assess sustained delivery and enhanced efficacy of pirfenidone-loaded nanoparticles after intratracheal instillation.Poly(lactide-co-glycolide) nanoparticles containing pirfenidone (NPs) were prepared and characterized. Biodistribution of N... |
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Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs.
Toxicol. Appl. Pharmacol. 274(2) , 328-38, (2014) Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported. In this study, the use of rat PCLS was investigated to further characterize the mechanism of early onset of fibrosis in this model and the effects of antifibroti... |
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A simple U-HPLC-MS/MS method for the determination of liensinine and isoliensinine in rat plasma.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 991 , 29-33, (2015) An ultra-high performance liquid chromatography tandem mass spectrometry (U-HPLC-MS/MS) method was developed and validated to determine liensinine and isoliensinine in rat plasma simultaneously. Plasma samples were prepared using protein precipitation with ac... |
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Determination of trifolirhizin in rat plasma by UPLC: Application to a pharmacokinetic study.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 990 , 181-4, (2015) In this study, a simple, sensitive, and robust analytical method based on ultra-performance liquid chromatography (UPLC) has been developed for the determination of trifolirhizin in rat plasma using pirfenidone as internal standard (IS). After sample preparat... |
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A simple method for the determination of Bosutinib in rat plasma by UPLC-MS/MS.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1004 , 93-7, (2015) In this work, a simple, sensitive and fast ultra performance liquid chromatography with tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the quantitative determination of bosutinib in rat plasma. Plasma samples were processed with ... |
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Antifibrotic therapy in simian immunodeficiency virus infection preserves CD4+ T-cell populations and improves immune reconstitution with antiretroviral therapy.
J. Infect. Dis. 211(5) , 744-54, (2015) Even with prolonged antiretroviral therapy (ART), many human immunodeficiency virus-infected individuals have <500 CD4(+) T cells/µL, and CD4(+) T cells in lymphoid tissues remain severely depleted, due in part to fibrosis of the paracortical T-cell zone (TZ)... |
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Pirfenidone inhibits macrophage infiltration in 5/6 nephrectomized rats.
Am. J. Physiol. Renal Physiol. 304(6) , F676-85, (2013) Tubulointerstitial macrophage infiltration is a hallmark of chronic kidney disease involved in the progression of renal fibrosis. Pirfenidone is a newly identified antifibrotic drug, the potential mechanism of which remains unclear. The aim of this study was ... |
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Efficient delivery to human lung fibroblasts (WI-38) of pirfenidone incorporated into liposomes modified with truncated basic fibroblast growth factor and its inhibitory effect on collagen synthesis in idiopathic pulmonary fibrosis.
Biol. Pharm. Bull. 38(2) , 270-6, (2015) In the present in vitro study, we assessed the delivery of pirfenidone incorporated into liposomes modified with truncated basic fibroblast growth factor (tbFGF) to lung fibroblasts and investigated the anti-fibrotic effect of the drug. The tbFGF peptide, KRT... |