acetazolamide
acetazolamide structure
|
Common Name | acetazolamide | ||
|---|---|---|---|---|
| CAS Number | 59-66-5 | Molecular Weight | 222.245 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C4H6N4O3S2 | Melting Point | 256-261°C | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
cIEF for rapid pKa determination of small molecules: a proof of concept.
Eur. J. Pharm. Sci. 63 , 14-21, (2014) A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) were compared: (i) a hydroxypropylcellulose (HPC) coated cap... |
|
|
Fast targeted analysis of 132 acidic and neutral drugs and poisons in whole blood using LC-MS/MS.
Forensic Sci. Int. 243 , 35-43, (2014) The aim of this study was to develop an LC-MS/MS based screening technique that covers a broad range of acidic and neutral drugs and poisons by combining a small sample volume and efficient extraction technique with simple automated data processing. After pro... |
|
|
Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
J. Neurosci. 35(14) , 5664-79, (2015) The Ca(2+) channelopathies caused by mutations of the CACNA1A gene that encodes the pore-forming subunit of the human Cav2.1 (P/Q-type) voltage-gated Ca(2+) channel include episodic ataxia type 2 (EA2). Although, in EA2 the emphasis has been on cerebellar dys... |
|
|
Characterization of carbonic anhydrase XIII in the erythrocytes of the Burmese python, Python molurus bivittatus.
Comp. Biochem. Physiol. B Biochem. Mol. Biol. 187 , 71-7, (2015) Carbonic anhydrase (CA) is one of the most abundant proteins found in vertebrate erythrocytes with the majority of species expressing a low activity CA I and high activity CA II. However, several phylogenetic gaps remain in our understanding of the expansion ... |
|
|
Cardiac responses to hypercapnia in larval zebrafish (Danio rerio): the links between CO2 chemoreception, catecholamines and carbonic anhydrase.
J. Exp. Biol. 217(Pt 19) , 3569-78, (2014) The ontogeny of carbon dioxide (CO2) sensing in zebrafish (Danio rerio) has not been examined. In this study, CO2-mediated increases in heart rate were used to gauge the capacity of zebrafish larvae to sense CO2. CO2 is thought to be detected via neuroepithel... |
|
|
Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain.
J. Neuroinflammation 12 , 113, (2015) The present study was proposed to elucidate the prophylactic role of curcumin in the prevention of hypoxia-induced cerebral edema (HACE).Rats were exposed to simulated hypobaric hypoxia at 7620 m for 24 h at 25 ± 1 °C. Transvascular leakage, expression of tra... |
|
|
Carbachol-induced colonic mucus formation requires transport via NKCC1, K⁺ channels and CFTR.
Pflugers Arch. 467 , 1403-15, (2015) The colonic mucosa protects itself from the luminal content by secreting mucus that keeps the bacteria at a distance from the epithelium. For this barrier to be effective, the mucus has to be constantly replenished which involves exocytosis and expansion of t... |
|
|
Intramitochondrial adenylyl cyclase controls the turnover of nuclear-encoded subunits and activity of mammalian complex I of the respiratory chain.
Biochim. Biophys. Acta 1853(1) , 183-91, (2015) In mammalian cells the nuclear-encoded subunits of complex I are imported into mitochondria, where they are assembled with mt-DNA encoded subunits in the complex, or exchanged with pre-existing copies in the complex. The present work shows that in fibroblast ... |
|
|
Preparation and evaluation of sustained release calcium alginate beads and matrix tablets of acetazolamide.
Drug Res. (Stuttg.) 63(2) , 60-4, (2013) The aim of this study was to develop sustained release dosage forms of acetazolamide (ACZ) preparing its calcium alginate beads and matrix tablets. ACZ was incorporated into calcium alginate beads using microencapsulation method. Two methods were applied to p... |
|
|
Pulmonary delivery of pyrazinamide-loaded large porous particles.
Eur. J. Pharm. Biopharm. 94 , 241-50, (2015) We have improved the aerodynamic properties of pyrazinamide loaded large porous particles (PZA-LPPs) designed for pulmonary delivery. To overcome the segregation of the different components occurring during the spray drying process and to obtain homogeneous L... |