T-2 Tetraol
T-2 Tetraol structure
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Common Name | T-2 Tetraol | ||
|---|---|---|---|---|
| CAS Number | 34114-99-3 | Molecular Weight | 298.332 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 515.2±50.0 °C at 760 mmHg | |
| Molecular Formula | C15H22O6 | Melting Point | 125°C- 135 °C | |
| MSDS | N/A | Flash Point | 265.4±30.1 °C | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
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Occurrence and distribution of 13 trichothecene toxins in naturally contaminated maize plants in Germany.
Toxins (Basel.) 4(10) , 778-87, (2012) The objective of the present study was to monitor the occurrence and distribution of a spectrum of trichothecene toxins in different parts of maize plants. Therefore maize plants were sampled randomly from 13 fields in southwest Germany and the fractions kern... |
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The natural occurrence of T-2 toxin and fumonisins in maize samples in Croatia.
Bull. Environ. Contam. Toxicol. 88(6) , 863-6, (2012) Maize (Zea mays) considered to be one of the most frequent crops in Croatia, is often contaminated with Fusarium mycotoxins. The aim of this study was to investigate the possible contamination of maize with T-2 toxin and fumonisins on 46 samples from differen... |
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Production of T-2 toxin and related trichothecenes on different media.
Acta Vet. Hung. 32(3-4) , 147-52, (1984)
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Biosynthesis of mevinolin, a hypocholesterolemic fungal metabolite, in Aspergillus terreus.
Proc. Natl. Sci. Counc. Repub. China. B. 11(3) , 223-31, (1987) Mevinolin and compactin are fungal metabolites which inhibit cholesterol biosynthesis in mammalian systems. Biogenetically, mevinolin is formed from polyketide chains, one 18-carbon and one 4-carbon, derived from acetate in normal head to tail fashion. The re... |
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Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture.
Toxicology 258(2-3) , 106-15, (2009) T-2 toxin belongs to the large group of trichothecene mycotoxins synthesized by various Fusarium molds which can infect raw agriculture materials. Among the trichothecenes, T-2 toxin is one of the most potent mycotoxins and poses a potential health risk in hu... |
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Structural characterization of metabolites after the microbial degradation of type A trichothecenes by the bacterial strain BBSH 797.
Food Addit. Contam. 19(4) , 379-86, (2002) Contamination of feed with trichothecenes, a group of Fusarium mycotoxins, leads to losses in performance due to their immunosupressive effects and the negative effect on the gastrointestinal system in animal production. A possible way of detoxification is mi... |
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A survey of the natural occurrence of Fusarium mycotoxins in cereals grown in New Zealand in 1986-1989.
Food Addit. Contam. 8(5) , 599-605, (1991) Fusarium mycotoxins, principally trichothecenes, occurred commonly in grain from crops in the North Island of New Zealand, but were much less common and also at the much lower levels in grains from South Island regions. The principal contaminants were trichot... |
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In vivo effects of T-2 mycotoxin on synthesis of proteins and DNA in rat tissues.
Toxicol. Appl. Pharmacol. 105(3) , 483-91, (1990) Rats were given an ip injection of T-2 mycotoxin (T-2), the T-2 metabolite, T-2 tetraol (tetraol), or cycloheximide. Serum, liver, heart, kidney, spleen, muscle, and intestine were collected at 3, 6, and 9 hr postinjection after a 2-hr pulse at each time with... |
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Structures of deepoxytrichothecene metabolites from 3'-hydroxy HT-2 toxin and T-2 tetraol in rats.
Appl. Environ. Microbiol. 50(3) , 676-9, (1985) 3'-Hydroxy HT-2 toxin and T-2 tetraol, in vivo metabolites of T-2 toxin, were orally administered to Wistar rats, and four metabolites having a trichothec-9,12-diene nucleus, which were termed deepoxytrichothecenes, were newly found in the excreta. Their stru... |
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Protein synthesis by mammalian cells treated with C-3-modified analogs of the 12,13-epoxytrichothecenes T-2 and T-2 tetraol.
Appl. Environ. Microbiol. 50(4) , 914-8, (1985) Modification at the C-3 position of the trichothecenes T-2 and T-2 tetraol affected their ability to inhibit protein synthesis in African green monkey kidney (Vero) and mouse erythroleukemia cells. Replacement of the 3-hydroxyl of T-2 with hydrogen caused a 2... |