4-Fluoro-L-phenylalanine
4-Fluoro-L-phenylalanine structure
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Common Name | 4-Fluoro-L-phenylalanine | ||
|---|---|---|---|---|
| CAS Number | 51-65-0 | Molecular Weight | 183.180 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 313.3±32.0 °C at 760 mmHg | |
| Molecular Formula | C9H10FNO2 | Melting Point | 253-255ºC | |
| MSDS | Chinese USA | Flash Point | 143.3±25.1 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Determination of homocysteine in cerebrospinal fluid as an indicator for surgery treatment in patients with hydrocefalus.
Physiol. Res. 63(4) , 521-7, (2014) Increased homocysteine levels in serum are typical features of neurodegenerative brain diseases including hydrocephalus. The most frequent therapeutic approach consists of the insertion of a shunt, connecting the brain ventricles to an alternative drainage si... |
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Simultaneous determination of gabapentin, pregabalin, vigabatrin, and topiramate in plasma by HPLC with fluorescence detection.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 962 , 82-8, (2014) Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) has been recognized as a useful tool in management of epilepsy. We developed a simple analytical method for simultaneous determination of four second generation AEDs, including gabapentin (GBP), ... |
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Studies on the inhibition of Moloney murine leukemia virus reverse transcriptase by N-tritylamino acids and N-tritylamino acid-nucleotide compounds.
Nucleosides Nucleotides Nucleic Acids 27 , 1011-1023, (2008) N-Acylated derivatives of 8-(6-aminohexyl) amino-adenosine-5 '-phosphate were prepared and studied with regard to their effect on DNA synthesis by the Moloney leukemia virus reverse transcriptase. N-palmitoyl and N-nicotinyl derivatives and bis-8-(6-aminohexy... |
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Design, synthesis, pharmacological evaluation, and structure-activity study of novel endomorphin analogues with multiple structural modifications.
J. Med. Chem. 54 , 1462-72, (2011) This study reports on new proteolytically stable, pharmacologically active endomorphin analogues, incorporating Dmt(1), Achc(2), pFPhe(4), or βMePhe(4) unnatural amino acids. Consistent with earlier results, it was found that the analogues carrying Dmt(1) and... |
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(De)regulation of key enzyme steps in the shikimate pathway and phenylalanine-specific pathway of the actinomycete Amycolatopsis methanolica.
Microbiology 149 , 3321-3330, (2003) Prephenate dehydratase (PDT), chorismate mutase (CM) and 3-deoxy-D-arabino-7-heptulosonate 7-phosphate (DAHP) synthase are key regulatory enzymes in aromatic amino acid biosynthesis in the actinomycete Amycolatopsis methanolica. Deregulated, feedback-control-... |
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Comparison of two alternative dominant selectable markers for wine yeast transformation.
Appl. Environ. Microbiol. 70 , 7018-7023, (2004) Genetic improvement of industrial yeast strains is restricted by the availability of selectable transformation markers. Antibiotic resistance markers have to be avoided for public health reasons, while auxotrophy markers are generally not useful for wine yeas... |
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Protein tyrosine kinase p56lck-deficiency confers hypersusceptibility to rho-fluorophenylalanine (pFPhe)-induced apoptosis by augmenting mitochondrial apoptotic pathway in human Jurkat T cells.
Biochem. Biophys. Res. Commun. 377 , 280-285, (2008) Phenylalanine analog, rho-fluorophenylalanine (pFPhe)-mediated cytotoxicity and several apoptotic events including mitochondrial cytochrome c release, activation of caspase-9, -3, and -8, Bid cleavage, degradation of PARP and PLCgamma-1, and DNA fragmentation... |
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Overproduction of 2-phenylethanol by industrial yeasts to improve organoleptic properties of bakers' products
Int. J. Food Microbiol. 180 , 7-12, (2014) 2-Phenylethanol (PEA), an important alcohol derived from phenylalanine, is involved in aroma and flavour of bakers' products. Four spontaneous mutants of an industrial bakers' yeast, V1 strain, were isolated for their resistance to p-fluoro-DL-phenylalanine (... |