(E)-Guggulsterone
(E)-Guggulsterone structure
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Common Name | (E)-Guggulsterone | ||
|---|---|---|---|---|
| CAS Number | 39025-24-6 | Molecular Weight | 312.446 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 463.3±45.0 °C at 760 mmHg | |
| Molecular Formula | C21H28O2 | Melting Point | 170-171.5° | |
| MSDS | Chinese USA | Flash Point | 172.3±25.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone.
Biochim. Biophys. Acta 1844(9) , 1684-93, (2014) Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative function of FXR is governed by conformational changes of t... |
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Guggulsterone attenuates cerulein-induced acute pancreatitis via inhibition of ERK and JNK activation.
Int. Immunopharmacol. 26 , 194-202, (2015) Guggulsterone (GS), a plant steroid and a compound found at high levels in Commiphora myrrha, exhibits anti-inflammatory, anti-cancer, and cholesterol-lowering effects. However, the potential of GS to ameliorate acute pancreatitis (AP) is unknown. The aim of ... |
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CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.
Mol. Pharmacol. 87(5) , 878-89, (2015) Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic sensors that enhance the detoxification and elimination of xenobiotics and endobiotics by modulating the expression of genes encoding drug-metabolizing enzymes and transporter... |
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Reversion of P-glycoprotein-mediated multidrug resistance by guggulsterone in multidrug-resistant human cancer cell lines.
Eur. J. Pharmacol. 694(1-3) , 39-44, (2012) Multidrug resistance (MDR) presents a serious problem in cancer chemotherapy. Our previous studies have shown that guggulsterone could reverse MDR through inhibiting the function and expression of P-glycoprotein (P-gp). The present study is to further investi... |
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Src-mediated cross-talk between farnesoid X and epidermal growth factor receptors inhibits human intestinal cell proliferation and tumorigenesis.
PLoS ONE 7(10) , e48461, (2012) Besides its essential role in controlling bile acid and lipid metabolism, the farnesoid X receptor (FXR) protects against intestinal tumorigenesis by promoting apoptosis and inhibiting cell proliferation. However, the mechanisms underlying these anti-prolifer... |
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Enhanced antitumor effect of combination therapy with gemcitabine and guggulsterone in pancreatic cancer.
Pancreas 41(7) , 1048-57, (2012) Guggulsterone is a dietary plant sterone possessing therapeutic potential against cancers. However, the antitumor effect of this natural compound on pancreatic cancer has not been determined yet. This study was designed to investigate the therapeutic efficacy... |
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Hypolipidemic agent Z-guggulsterone: metabolism interplays with induction of carboxylesterase and bile salt export pump.
J. Lipid Res. 53(3) , 529-39, (2012) Z-Guggulsterone is a major ingredient in the Indian traditional hypolipidemic remedy guggul. A study in mice has established that its hypolipidemic effect involves the farnesoid X receptor (FXR), presumably by acting as an antagonist of this receptor. It is g... |
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TO901317 regulating apolipoprotein M expression mediates via the farnesoid X receptor pathway in Caco-2 cells.
Lipids Health Dis. 10 , 199, (2011) Apolipoprotein M (apoM) may have potential antiatherosclerotic properties. It has been reported that apoM expression could be regulated by many intracellar and extracellar factors. In the present study we further investigated regulation of apoM expression in ... |
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Guggulsterone suppresses LPS induced inflammation of human middle ear epithelial cells (HMEEC)
Int. J. Pediatr. Otorhinolaryngol. 74(12) , 1384-7, (2010) Objective Guggulsterone is a bioactive constituent of resinous sap originating from the guggul tree, Commiphora mukul, which has been used over several thousands of years to treat various diseases, including atherosclerosis, rheumatism, and obesity. However, ... |
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Effective separation and analysis of E- and Z-guggulsterones in Commiphora mukul resin, guggulipid and their pharmaceutical product by high performance thin-layer chromatography-densitometric method.
J. Pharm. Biomed. Anal. 56(2) , 240-5, (2011) A high performance thin-layer chromatographic (HPTLC) method for the simultaneous determination of the hypolipidemic agents, E- and Z-isomers of guggulsterone in Commiphora mukul resin, guggulipid (ethyl acetate extract of resin), and its pharmaceutical formu... |