Prinaberel
Prinaberel structure
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Common Name | Prinaberel | ||
|---|---|---|---|---|
| CAS Number | 524684-52-4 | Molecular Weight | 271.243 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 451.6±45.0 °C at 760 mmHg | |
| Molecular Formula | C15H10FNO3 | Melting Point | 250-252ºC | |
| MSDS | Chinese USA | Flash Point | 226.9±28.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Genistein increases estrogen receptor beta expression in prostate cancer via reducing its promoter methylation.
J. Steroid Biochem. Mol. Biol. 152 , 62-75, (2015) Genistein has protective effects against prostate cancer (PCa) but whether this protection involves an estrogen receptor (ER) β dependent mechanism has yet to be elucidated. ER-β has a tumor suppressor role in PCa and its levels decline with cancer progressio... |
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Drug and cell type-specific regulation of genes with different classes of estrogen receptor beta-selective agonists.
PLoS ONE 7 , (2009) Estrogens produce biological effects by interacting with two estrogen receptors, ERalpha and ERbeta. Drugs that selectively target ERalpha or ERbeta might be safer for conditions that have been traditionally treated with non-selective estrogens. Several synth... |
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Mouse leydig cells with different androgen production potential are resistant to estrogenic stimuli but responsive to bisphenol a which attenuates testosterone metabolism.
PLoS ONE 8 , e71722, (2013) It is well known that estrogens and estrogen-like endocrine disruptors can suppress steroidogenic gene expression, attenuate androgen production and decrease differentiation of adult Leydig cell lineage. However, there is no information about the possible lin... |
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Estrogen receptor beta-selective agonists stimulate calcium oscillations in human and mouse embryonic stem cell-derived neurons.
PLoS ONE 5 , e11791, (2010) Estrogens are used extensively to treat hot flashes in menopausal women. Some of the beneficial effects of estrogens in hormone therapy on the brain might be due to nongenomic effects in neurons such as the rapid stimulation of calcium oscillations. Most stud... |