Dicoumarol
Dicoumarol structure
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Common Name | Dicoumarol | ||
|---|---|---|---|---|
| CAS Number | 66-76-2 | Molecular Weight | 336.295 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 620.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C19H12O6 | Melting Point | 290-292 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 231.9±25.0 °C | |
| Symbol |
GHS07, GHS08, GHS09 |
Signal Word | Danger | |
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Sulfation modulates the cell uptake, antiradical activity and biological effects of flavonoids in vitro: An examination of quercetin, isoquercitrin and taxifolin.
Bioorg. Med. Chem. 23 , 5402-9, (2015) Quercetin 3'-O-sulfate is one of the main metabolites of the natural flavonoid quercetin in humans. This study was designed to prepare quercetin 3'-O-sulfate (1), isoquercitrin 4'-O-sulfate (2) and taxifolin 4'-O-sulfate (3) by the sulfation of quercetin, iso... |
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Comparative Study of 17-AAG and NVP-AUY922 in Pancreatic and Colorectal Cancer Cells: Are There Common Determinants of Sensitivity?
Transl. Oncol. 7(5) , 590-604, (2014) The use of heat shock protein 90 (Hsp90) inhibitors is an attractive antineoplastic therapy. We wanted to compare the effects of the benzoquinone 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) and the novel isoxazole resorcinol-based Hsp90 inhi... |
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Impaired vitamin K recycling in uremia is rescued by vitamin K supplementation.
Kidney Int. 86(2) , 286-93, (2014) In chronic kidney disease, vitamin K-dependent proteins, including the calcification inhibitor matrix Gla protein, are largely uncarboxylated indicating that functional vitamin K deficiency may contribute to uremic vascular calcification. Since the effects of... |
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The effect of cloudy apple juice on hepatic and mammary gland phase I and II enzymes induced by DMBA in female Sprague-Dawley rats.
Drug Chem. Toxicol. 37(4) , 472-9, (2014) Apples abundant in phenolic compounds show a variety of biological activities that may contribute to health beneficial effects against cardiovascular diseases, diabetes, obesity and cancer. We investigated the effect of cloudy apple juice (CAJ) on the hepatic... |
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Areca nut components affect COX-2, cyclin B1/cdc25C and keratin expression, PGE2 production in keratinocyte is related to reactive oxygen species, CYP1A1, Src, EGFR and Ras signaling.
PLoS ONE 9(7) , e101959, (2014) Chewing of betel quid (BQ) increases the risk of oral cancer and oral submucous fibrosis (OSF), possibly by BQ-induced toxicity and induction of inflammatory response in oral mucosa.Primary gingival keratinocytes (GK cells) were exposed to areca nut (AN) comp... |
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Dicoumarol activates Ca2+-permeable cation channels triggering erythrocyte cell membrane scrambling.
Cell Physiol. Biochem. 28(5) , 857-64, (2011) Dicoumarol, a widely used anticoagulant, may cause anemia, which may result from enhanced erythrocyte loss due to bleeding or due to accelerated erythrocyte death. Erythrocytes may undergo suicidal death or eryptosis, characterized by cell shrinkage and phosp... |
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Cytoprotective Effect of Afobazole and Its Main Metabolite M-11.
Bull. Exp. Biol. Med. 159 , 44-7, (2015) Cell damage depending on activity of quinone reductase 2 (MT3 receptor) was simulated in experiments on bone marrow cell suspension and assessed by menadione-induced DNA breaks measured by comet assay. We analyzed the protective effect of afobazole interactin... |
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Augmentation of NAD(+) by NQO1 attenuates cisplatin-mediated hearing impairment.
Cell Death Dis. 5 , e1292, (2014) Cisplatin (cis-diaminedichloroplatinum-II) is an extensively used chemotherapeutic agent, and one of its most adverse effects is ototoxicity. A number of studies have demonstrated that these effects are related to oxidative stress and DNA damage. However, the... |
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NAD(P)H:quinone oxidoreductase 1 activation reduces blood pressure through regulation of endothelial nitric oxide synthase acetylation in spontaneously hypertensive rats.
Am. J. Hypertens. 28(1) , 50-7, (2014) Endothelial nitric oxide synthase (eNOS) is involved in blood pressure (BP) regulation through the production of nitric oxide. Sirtuin I (SIRT1), an NAD-dependent protein deacetylase, promotes vascular relaxation through deacetylation and activation of eNOS. ... |
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Inhibitory effects and oxidative target site of dibutyl phthalate on Karenia brevis.
Chemosphere 132 , 32-9, (2015) The inhibitory action and possible damage mechanism of dibutyl phthalate (DBP) on the red tide algae Karenia brevis were investigated. The results showed that the algae experienced oxidative stress after exposure to 5mgL(-1) DBP. Malondialdehyde (MDA) peaked ... |