Jatrorrhizine
Jatrorrhizine structure
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Common Name | Jatrorrhizine | ||
|---|---|---|---|---|
| CAS Number | 3621-38-3 | Molecular Weight | 338.377 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H20NO4+ | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS09 |
Signal Word | Warning | |
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Effect of jatrorrhizine on delayed gastrointestinal transit in rat postoperative ileus.
J. Pharm. Pharmacol. 64(3) , 413-9, (2012) Postoperative ileus is major cause of postoperative complication and prolonged hospitalization. Jatrorrhizine, which is a protoberberine alkaloid isolated from the medicinal plants Berberis aristata and Coptis chinensis, has been found to increase contractili... |
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Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein.
Xenobiotica 41(4) , 290-6, (2011) The absorption and transport mechanisms of berberine, palmatine, jateorhizine, and coptisine were studied using a Caco-2 cells uptake and transport model, with the addition of cyclosporin A and verapamil as P-glycoprotein (P-gp) inhibitors and MK-571 as a mul... |
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Pharmacokinetics and metabolism of jatrorrhizine, a gastric prokinetic drug candidate.
Biopharm. Drug Dispos. 33(3) , 135-45, (2012) Jatrorrhizine, a protoberberine alkaloid derived from Coptis chinensis, is currently under investigation as a natural gastric prokinetic drug candidate. In vitro and in vivo studies were conducted to characterize its pharmacokinetics and metabolism. After int... |
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Rhizoma coptidisand berberine-induced activation of murine microglia N9 cells
J. Ethnopharmacol. 129(1) , 121-6, (2010) Murine microglia N9 cells were activated by both the water extract of Rhizoma coptidis (WEC) and berberine by the regulation of mitochondrial Δψ, free radicals, as well as three genes of Ndufab1, Cox6a2 and Atp5a1. However, WEC induced this activation more re... |
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The effects of jatrorrhizine on contractile responses of rat ileum
Eur. J. Pharmacol. 663(1-3) , 74-9, (2011) This study was designed to evaluate the effect of jatrorrhizine on smooth muscle contractions isolated from rat ileum longitudinal muscles. Jatrorrhizine increased the amplitude of spontaneous contractions of ileum longitudinal muscles in concentration-depend... |
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Isoquinoline alkaloids from Tinospora cordifolia inhibit rat lens aldose reductase.
Phytother Res. 26(9) , 1342-7, (2012) The inhibitory activity of Tinospora cordifolia stem-derived alkaloids was evaluated against lens aldose reductase (AR) isolated from male Wistar rats. Anticataract potential of the alkaloids of T. cordifolia was evaluated in vitro in rat lenses, considering ... |
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Chinese herbal medicinal ingredients inhibit secretion of IL-6, IL-8, E-selectin and TXB2 in LPS-induced rat intestinal microvascular endothelial cells.
Immunopharmacol. Immunotoxicol. 31(4) , 550-5, (2009) The aim of the research was to investigate the anti-inflammatory mechanism of Pulsatillae Decoction (PD), the levels of interleukin (IL)-6, IL-8, E-selectin, and thromboxane B(2) (TXB(2)) secreted by cultured rat intestinal microvascular endothelial cells (RI... |
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Involvement of rat organic cation transporter 2 in the renal uptake of jatrorrhizine.
J. Pharm. Sci. 102(4) , 1333-42, (2013) Jatrorrhizine is a protoberberine alkaloid derived from Coptis chinensis concentrated extremely in rat kidney. In the present study, the involvement of rat organic cation transporter 2 (rOCT2) in the renal uptake of jatrorrhizine in rat was investigated throu... |
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Neuroprotective effect of Jatrorrhizine on hydrogen peroxide-induced cell injury and its potential mechanisms in PC12 cells.
Neurosci. Lett. 498(3) , 227-31, (2011) The neuroprotective effects of Jatrorrhizine from Coptidis Rhizoma against hydrogen peroxide (H(2)O(2))-induced rat pheochromocytoma line PC12 injury and its potential mechanisms were evaluated in the present study. When cells were exposed to H(2)O(2) (200 μM... |
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Discrimination of Phellodendron amurense and P. chinense based on DNA analysis and the simultaneous analysis of alkaloids.
Arch. Pharm. Res. 35(6) , 1045-54, (2012) Phellodendri Cortex is the bark of the stems of Phellodendron amurense Ruprecht or P. chinense Schneider (Rutaceae), which is orginated from periderm. The internal transcribed spacer sequences of 20 originated plants and identified samples were analyzed. The ... |