pramiracetam
pramiracetam structure
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Common Name | pramiracetam | ||
|---|---|---|---|---|
| CAS Number | 68497-62-1 | Molecular Weight | 269.383 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 461.0±30.0 °C at 760 mmHg | |
| Molecular Formula | C14H27N3O2 | Melting Point | 47 °C | |
| MSDS | Chinese USA | Flash Point | 232.6±24.6 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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The effects of cholinergic drugs support an avoidance learning hypothesis of brief footshock-induced analgesia.
Neuropharmacology 25(10) , 1161-6, (1986) Rats were tested for tail-flick responses and then immediately subjected to footshock for 30 sec. This procedure induced analgesia, i.e. prolonged the latency of the tail-flick response, which was maximal immediately after the shock and decayed to normal leve... |
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The memory-enhancing effects of the piracetam-like nootropics are dependent on experimental parameters.
Behav. Brain Res. 33(1) , 79-82, (1989) The effects of the nootropic agent piracetam and its congeners oxiracetam, pramiracetam and aniracetam on the retention performance of mice in a passive-avoidance situation are dependent on the intensity of the foot-shock applied. This phenomenon is observed ... |
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Gas chromatographic assay of pramiracetam in human plasma using nitrogen specific detection.
J. Chromatogr. A. 274 , 346-9, (1983)
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Pharmacokinetics of pramiracetam in healthy volunteers after oral administration.
Int. J. Clin. Pharmacol. Res. 12(3) , 129-32, (1992) The pharmacokinetics of pramiracetam was assessed using an HPLC method after oral administration of two different formulations of 600 mg (a solution and a tablet) of pramiracetam to 11 fasting volunteers. The mean kinetic parameters were: t1 = 4.7 +/- 2.4 - 4... |
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Pramiracetam and epileptic after-discharges in young rats after hypoxia.
Act. Nerv. Super. (Praha.) 31(1) , 68-9, (1989)
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Pharmacokinetics of oral pramiracetam in normal volunteers.
J. Clin. Pharmacol. 25(4) , 291-5, (1985) The pharmacokinetics of pramiracetam, a new, investigational, cognition activator, were assessed in normal male volunteers as part of a clinical tolerance study. In a double-blind, randomized design, two groups of six subjects each received alternating placeb... |
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Systemic administration of pramiracetam increases nitric oxide synthase activity in the cerebral cortex of the rat.
Funct. Neurol. 10(3) , 151-5, (1995) The effect of systemic administration of pramiracetam on neuronal type nitric oxide synthase (NOS) activity and NOS mRNA expression were studied in the hippocampus and cerebral cortex in rats. A dose of 300 mg/kg (i.p.) of this nootropic produced an approxima... |
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The action of pramiracetam on consequences of hypobaric hypoxia is only moderate.
Physiol. Res. 45(3) , 245-8, (1996) The possible protective action of pramiracetam, a pyrrolidinone nootropic drug, against hypobaric hypoxia was studied in two age groups of immature rats with implanted electrodes. Epileptic afterdischarges induced by hippocampal stimulation were used as a mea... |
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Amnesia-reversal activity of a series of N-[(disubstituted-amino)alkyl] -2-oxo-1-pyrrolidineacetamides, including pramiracetam.
J. Med. Chem. 27(5) , 684-91, (1984) A series of N-[(dialkylamino)alkyl]-2-oxo-1- pyrrolidineacetamides was synthesized. The title compounds reversed electroconvulsive shock (ECS) induced amnesia in mice when administered subsequent to the ECS treatment and were inactive in a general observation... |
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The effect of pramiracetam (CI-879) on the acquisition of a radial arm maze task.
Psychopharmacology 89(3) , 378-81, (1986) The effect of the nootropic drug pramiracetam (CI-879) on acquisition of a radial arm maze task was examined in the rat. Two doses of pramiracetam (7.5 mg/kg and 15 mg/kg) were administered daily prior to testing for 7 weeks in a 16-arm radial maze in which n... |