Ethanethioic acid,S-(triphenylmethyl) ester

Ethanethioic acid,S-(triphenylmethyl) ester Structure
Ethanethioic acid,S-(triphenylmethyl) ester structure
Common Name Ethanethioic acid,S-(triphenylmethyl) ester
CAS Number 1727-15-7 Molecular Weight 318.43200
Density 1.15g/cm3 Boiling Point 433.5ºC at 760mmHg
Molecular Formula C21H18OS Melting Point 141-144ºC(lit.)
MSDS USA Flash Point 184.4ºC

Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.

J. Med. Chem. 51 , 1115-25, (2008)

The human kinesin Eg5 is a potential drug target for cancer chemotherapy. Eg5 specific inhibitors cause cells to block in mitosis with a characteristic monoastral spindle phenotype. Prolonged metaphase block eventually leads to apoptotic cell death. S-trityl-...