3-Hydroxy-2-naphthoic acid

3-Hydroxy-2-naphthoic acid Structure
3-Hydroxy-2-naphthoic acid structure
Common Name 3-Hydroxy-2-naphthoic acid
CAS Number 92-70-6 Molecular Weight 188.179
Density 1.4±0.1 g/cm3 Boiling Point 367.7±25.0 °C at 760 mmHg
Molecular Formula C11H8O3 Melting Point 218-221 °C(lit.)
MSDS Chinese USA Flash Point 190.4±19.7 °C
Symbol GHS07
GHS07
Signal Word Warning

Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs.

Bioorg. Med. Chem. 15 , 6535-48, (2007)

A series of compounds containing one or two salicylic acid moieties were synthesized, and their efficacy to inhibit the phosphohydrolase activity of PTP1B examined. Some of the methylenedisalicylic acid derivatives were potent inhibitors of PTP1B. Of those de...

Coupling solid-phase microextraction and laser desorption ionization for rapid identification of biological material.

Rapid Commun. Mass Spectrom. 26 , 853-862, (2012)

Solid phase microextraction (SPME) use small fibers directly plunged in the solution under investigation to quickly extract and quantify by different techniques the amount of selected dissolved compounds.Biological materials, peptides or proteins are accurate...

Hydrazide and hydrazine reagents as reactive matrices for MALDI-MS to detect gaseous aldehydes.

J. Mass Spectrom. 49(8) , 742-9, (2014)

The reagents 19 hydrazide and 14 hydrazine were examined to function as reactive matrices for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) to detect gaseous aldehydes. Among them, two hydrazide (2-hydroxybenzohydrazide and 3-hydrox...

Energy transfer photophysics from serum albumins to sequestered 3-hydroxy-2-naphthoic acid, an excited state intramolecular proton-transfer probe.

J. Phys. Chem. B 112(11) , 3451-61, (2008)

The steady-state and time-resolved studies of the sensitized emission of the excited-state proton transfer (ESIPT) probe 3-hydroxy-2-naphthoic acid (3HNA) when bound to bovine serum albumin (BSA) and human serum albumin (HSA) indicate that the nonradiative di...

Guest-controlling effects on ER behaviors of beta-cyclodextrin polymer.

J. Colloid. Interface Sci. 289(1) , 56-62, (2005)

An effective and novel approach to obtaining electrorheological particles with high performance through the formation of host-guest complexes has been achieved. The significant preponderance of the host-guest complex formation is that the host structure can b...

Spectrofluorimetric determination of 3-hydroxy-2-naphthoic acid by use of its ternary complex with zirconium (IV) and beta-cyclodextrin: application to determination in river water.

J. Fluoresc. 17(1) , 23-8, (2007)

A spectrofluorimetric method has been developed for the determination of 3-hydroxy-2-naphthoic acid (3H2NA) by formation of a ternary complex with zirconium (IV) and beta-cyclodextrin (beta-CD). It has been observed that the fluorescence intensity of 3H2NA is...

Novel indoleamine 2,3-dioxygenase-1 inhibitors from a multistep in silico screen.

Bioorg. Med. Chem. 20 , 1354-63, (2012)

Indoleamine 2,3-dioxygenase-1 (IDO-1) is a heme containing enzyme that catalyses the initial step in the major pathway of l-tryptophan catabolism; the kynurenine pathway. A large body of evidence has been accumulating for its immunosuppressive and tumoural es...