p-Toluidine
p-Toluidine structure
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Common Name | p-Toluidine | ||
|---|---|---|---|---|
| CAS Number | 106-49-0 | Molecular Weight | 107.153 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 197.4±9.0 °C at 760 mmHg | |
| Molecular Formula | C7H9N | Melting Point | 41-46 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 88.9±0.0 °C | |
| Symbol |
GHS06, GHS08, GHS09 |
Signal Word | Danger | |
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miR-145 suppress the androgen receptor in prostate cancer cells and correlates to prostate cancer prognosis.
Carcinogenesis 36 , 858-66, (2015) Androgen signalling through the androgen receptor (AR) is essential for prostate cancer initiation, progression and transformation to the lethal castration-resistant state. The aim of this study was to characterize the mechanisms by which miR-145 deregulation... |
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Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
J. Med. Chem. 48 , 3269-79, (2005) Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm of the partition coefficient of the neutral species in the... |
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QUANTITY: An Isobaric Tag for Quantitative Glycomics.
Sci. Rep. 5 , 17585, (2015) Glycan is an important class of macromolecules that play numerous biological functions. Quantitative glycomics--analysis of glycans at global level--however, is far behind genomics and proteomics owing to technical challenges associated with their chemical pr... |
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Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation.
Drug Metab. Dispos. 43(1) , 126-39, (2014) Although skin is the largest organ of the human body, cutaneous drug metabolism is often overlooked, and existing experimental models are insufficiently validated. This proof-of-concept study investigated phase II biotransformation of 11 test substrates in fr... |
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Aldehyde oxidase activity in fresh human skin.
Drug Metab. Dispos. 42(12) , 2049-57, (2014) Human aldehyde oxidase (AO) is a molybdoflavoenzyme that commonly oxidizes azaheterocycles in therapeutic drugs. Although high metabolic clearance by AO resulted in several drug failures, existing in vitro-in vivo correlations are often poor and the extrahepa... |
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Ferrocene-based guanidine derivatives: in vitro antimicrobial, DNA binding and docking supported urease inhibition studies.
Eur. J. Med. Chem. 85 , 438-49, (2014) Some novel ferrocenyl guanidines 1-8 were synthesized and characterized by different spectroscopic methods, elemental analysis and single crystal X-rays diffraction techniques. The crystallographic studies revealed that the existence of the strong non-bonding... |
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Efficient production of secreted staphylococcal antigens in a non-lysing and proteolytically reduced Lactococcus lactis strain.
Appl. Microbiol. Biotechnol. 98(24) , 10131-41, (2014) Cell surface-exposed and secreted proteins are attractive targets for vaccination against pathogenic gram-positive bacteria. To obtain sufficient amounts of such antigens, efficient protein production platforms are needed. In this study, a pipeline for the pr... |
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Gonadotropin regulation and role of ovarian osteopontin in the periovulatory period.
J. Endocrinol. 224(1) , 49-59, (2014) Osteopontin (OPN), a secreted glycoprotein, has multiple physiological functions. This study investigated the regulation and roles of OPN in the mouse ovary during the periovulatory stages. Immature female mice were treated with pregnant mare serum gonadotrop... |
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Hypoxia-inducible factor 2 alpha is essential for hepatic outgrowth and functions via the regulation of leg1 transcription in the zebrafish embryo.
PLoS ONE 9(7) , e101980, (2014) The liver plays a vital role in metabolism, detoxification, digestion, and the maintenance of homeostasis. During development, the vertebrate embryonic liver undergoes a series of morphogenic processes known as hepatogenesis. Hepatogenesis can be separated in... |
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Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment.
Cancer. Immunol. Res. 2(3) , 274-85, (2014) Correcting T-cell immunosuppression may unleash powerful antitumor responses; however, knowledge about the mechanisms and modifiers that may be targeted to improve therapy remains incomplete. Here, we report that polyamine elevation in cancer, a common metabo... |