DEXTRORPHAN D-TARTRATE
DEXTRORPHAN D-TARTRATE structure
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Common Name | DEXTRORPHAN D-TARTRATE | ||
|---|---|---|---|---|
| CAS Number | 125-73-5 | Molecular Weight | 407.45700 | |
| Density | 1.17g/cm3 | Boiling Point | 410.4ºC at 760mmHg | |
| Molecular Formula | C21H29NO7 | Melting Point | ≥195ºC | |
| MSDS | Chinese USA | Flash Point | 207.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device.
Xenobiotica 45(1) , 29-44, (2014) 1. The quantitative prediction of the pharmacokinetic parameters of a drug from data obtained using human in vitro systems remains a significant challenge i.e. prediction of metabolic clearance in humans and estimation of the relative contribution of enzymes ... |
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Evaluation of thein vitro/in vivodrug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition
Food Chem. Toxicol. 68 , 117-27, (2014) • BST204 is a purified dry extract of ginseng containing high amounts of Rh2 and Rg3. • BST204 had only weak inhibitory effects on nine CYPs and five UGTs. • It is unlikely that BST204 alter pharmacokinetics of drugs metabolized by CYPs/UGTs. |
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Determination of sitafloxacin in human plasma by liquid chromatography–tandem mass spectrometry method: Application to a pharmacokinetic study
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 957 , 36-40, (2014) • An LC–MS/MS method has been developed for determining sitafloxacin in human plasma. • The method has some merits: high sensitivity, small sample volume and short runtime. • It is successfully applied to the pharmacokinetic study of sitafloxacin in human. |
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Phenotyping of CYP450 in human liver microsomes using the cocktail approach.
Anal. Bioanal. Chem 406(20) , 4875-87, (2014) The cocktail approach is an advantageous strategy used to monitor the activities of several cytochromes P450 (CYPs) in a single test to increase the throughput of in vitro phenotyping studies. In this study, a cocktail mixture was developed with eight CYP-spe... |
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Development and validation of a liquid-chromatography high-resolution tandem mass spectrometry approach for quantification of nine cytochrome P450 (CYP) model substrate metabolites in an in vitro CYP inhibition cocktail.
Anal. Bioanal. Chem 406(18) , 4453-64, (2014) Knowledge about the cytochrome P450 (CYP) inhibition potential of new drug candidates is important for drug development because of its risk of interactions. For novel psychoactive substances (NPS), corresponding data are not available. For developing a genera... |
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Comparison of liquid chromatography and supercritical fluid chromatography coupled to compact single quadrupole mass spectrometer for targeted in vitro metabolism assay.
J. Chromatogr. A. 1371 , 244-56, (2014) The goal of this study was to evaluate the combination of powerful chromatographic methods and compact single quadrupole MS device for simple in vitro cytochrome P450 (CYP) inhibition assay, instead of more expensive triple quadrupole MS/MS detectors. For thi... |
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Simultaneous determination of osthole, bergapten and isopimpinellin in rat plasma and tissues by liquid chromatography–tandem mass spectrometry
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 77-85, (2014) • Simultaneous determination of osthole, bergapten and isopimpinellin. • The validated method was applied to pharmacokinetic and tissue distribution. • Simultaneous analysis of three active compounds in gonad tissue was studied firstly |
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Size- and time-dependent alteration in metabolic activities of human hepatic cytochrome P450 isozymes by gold nanoparticles via microsomal coincubations.
Nanoscale Res. Lett. 9(1) , 642, (2014) Nano-sized particles are known to interfere with drug-metabolizing cytochrome P450 (CYP) enzymes, which can be anticipated to be a potential source of unintended adverse reactions, but the mechanisms underlying the inhibition are still not well understood. He... |
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CYP2D6-CYP2C9 protein-protein interactions and isoform-selective effects on substrate binding and catalysis.
Drug Metab. Dispos. 37(8) , 1682-9, (2009) Cytochrome P450 (P450) protein-protein interactions have been observed with various in vitro systems. It is interesting to note that these interactions seem to be isoform-dependent, with some combinations producing no effect and others producing increased or ... |
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Contribution of the activities of CYP3A, CYP2D6, CYP1A2 and other potential covariates to the disposition of methadone in patients undergoing methadone maintenance treatment.
Br. J. Clin. Pharmacol. 67(1) , 29-37, (2009) To investigate the influence of different cytochrome P450 (CYP) activities and other potential covariates on the disposition of methadone in patients on methadone maintenance therapy (MMT).Eighty-eight patients (58 male; 21-55 years; 84 White) on MMT were stu... |