AH13205
AH13205 structure
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Common Name | AH13205 | ||
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| CAS Number | 148436-63-9 | Molecular Weight | 388.54000 | |
| Density | 1.075g/cm3 | Boiling Point | 574.1ºC at 760mmHg | |
| Molecular Formula | C24H36O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 315.1ºC | |
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New reagent system for attaining high regio- and stereoselectivities in allylic displacement of 4-cyclopentene-1,3-diol monoacetate with aryl- and alkenylmagnesium bromides.
Org. Lett. 7(2) , 183-6, (2005) [Reaction: see text] Low regioselectivity of RMgBr (R = aryl, alkenyl) in the CuCN-catalyzed reaction with 4-cyclopentene-1,3-diol monoacetate is improved by addition of LiCl or MgCl2 to a similar extent as previously obtained with RMgCl (>90:10). The limitat... |
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Phospholipase A2 inhibitors protect against prion and Abeta mediated synapse degeneration.
Molecular Neurodegeneration 5 , 13, (2010) An early event in the neuropathology of prion and Alzheimer's diseases is the loss of synapses and a corresponding reduction in the level of synaptophysin, a pre-synaptic membrane protein essential for neurotransmission. The molecular mechanisms involved in s... |
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EP4 receptor as a new target for bronchodilator therapy.
Thorax 66(12) , 1029-35, (2011) Asthma and chronic obstructive pulmonary disease are airway inflammatory diseases characterised by airflow obstruction. Currently approved bronchodilators such as long-acting β(2) adrenoceptor agonists are the mainstay treatments but often fail to relieve sym... |
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Stimulation of cannabinoid (CB1) and prostanoid (EP2) receptors opens BKCa channels and relaxes ocular trabecular meshwork.
Exp. Eye Res. 80(5) , 697-708, (2005) Prostanoids and cannabinoids have ocular hypotensive and neuroprotective properties. The effect of the prostanoid AH13205 (EP2), the thromboxane-mimetic U46619, the cannabinoid (CB) agonists WIN55212-2 and CP 55,940, endothelin-1 (ET-1) and 8-bromo-cAMP on th... |
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Cobalt(diamine)-catalyzed cross-coupling reaction of alkyl halides with arylmagnesium reagents: stereoselective constructions of arylated asymmetric carbons and application to total synthesis of AH13205.
J. Am. Chem. Soc. 128(6) , 1886-9, (2006) A cobalt-diamine complex catalyzes the cross-coupling reactions of primary and secondary alkyl halides with aryl Grignard reagents. It is confirmed that oxidative addition of alkyl halide to cobalt proceeds via a radical process. Optically pure Ueno-Stork hal... |
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Characterization of the prostanoid receptor(s) on human blood monocytes at which prostaglandin E2 inhibits lipopolysaccharide-induced tumour necrosis factor-alpha generation.
Br. J. Pharmacol. 122(1) , 149-57, (1997) 1. The prostanoid receptor(s) that mediates inhibition of bacterial lipopolysaccharide (LPS)-induced tumour necrosis factor-alpha (TNF-alpha) generation from human peripheral blood monocytes was classified by use of naturally occurring and synthetic prostanoi... |
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Characterization of the inhibitory prostanoid receptors on human neutrophils.
Br. J. Pharmacol. 108(4) , 1051-4, (1993) 1. We have evaluated the effects of various prostanoid agonists on the release of leukotriene B4 (LTB4) and superoxide anions (O2-) from human neutrophils stimulated with opsonized zymosan (OZ) and formyl-methionyl-leucyl-phenylalanine (FMLP), respectively. 2... |
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Morphological changes in the anterior eye segment after long-term treatment with different receptor selective prostaglandin agonists and a prostamide.
Invest. Ophthalmol. Vis. Sci. 44(10) , 4419-26, (2003) To investigate long-term changes in the anterior segment of primate eyes treated for one year with different prostaglandin agonists and a prostamide. The results were compared with those obtained after vehicle treatment and in untreated controls.Sixteen young... |
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Evidence for the presence of AH 13205-sensitive EP2-prostanoid receptors in the pregnant baboon but not in the pregnant sheep myometrium near term.
J. Soc. Gynecol. Investig. 2(1) , 6-12, (1995) Our purposes were to assess the effects of prostaglandin (PG) E2 and PGF2 alpha on myometrial contractility in pregnant sheep and baboons in an in vitro superfusion study, and to characterize further the PGE-sensitive (EP) receptor subtype involved in the myo... |
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Characterization of dilator prostanoid receptors in the fetal rabbit ductus arteriosus.
J. Pharmacol. Exp. Ther. 271(1) , 390-6, (1994) The purpose of this study was to determine which receptors mediate the dilator effects of prostaglandins (PGs) on the ductus arteriosus of the fetal rabbit. Isolated rings of the vessel from fetal New Zealand White rabbits were precontracted with indomethacin... |