Endothelin-2 (human, canine) acetate salt
Endothelin-2 (human, canine) acetate salt structure
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Common Name | Endothelin-2 (human, canine) acetate salt | ||
|---|---|---|---|---|
| CAS Number | 123562-20-9 | Molecular Weight | 2546.92000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C115H160N26O32S4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Role of the endothelin axis in astrocyte- and endothelial cell-mediated chemoprotection of cancer cells.
Neuro. Oncol. 16(12) , 1585-98, (2014) Recent evidence suggests that astrocytes protect cancer cells from chemotherapy by stimulating upregulation of anti-apoptotic genes in those cells. We investigated the possibility that activation of the endothelin axis orchestrates survival gene expression an... |
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Cardiovascular changes in atherosclerotic ApoE-deficient mice exposed to Co60 (γ) radiation.
PLoS ONE 8 , e65486, (2013) There is evidence for a role of ionizing radiation in cardiovascular diseases. The goal of this work was to identify changes in oxidative and nitrative stress pathways and the status of the endothelinergic system during progression of atherosclerosis in ApoE-... |
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The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.
Proc. Natl. Acad. Sci. U. S. A. 86 , 2863-2867, (1989) Three distinct human endothelin-related genes were cloned by screening a genomic DNA library under a low hybridization stringency with a synthetic oligonucleotide probe encoding a portion of the endothelin sequence. Genomic Southern blot analysis with the sam... |
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Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis.
Proc. Natl. Acad. Sci. U. S. A. 110(40) , E3830-9, (2013) Endothelin signaling is required for neural crest migration and homeostatic regulation of blood pressure. Here, we report that constitutive overexpression of Endothelin-2 (Edn2) in the mouse retina perturbs vascular development by inhibiting endothelial cell ... |
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Expression of endothelin 2 and localized clear cell renal cell carcinoma.
Hum. Pathol. 43(6) , 843-9, (2012) Despite the rising incidence of clear cell renal cell carcinoma, the molecular events that support its development and progression remain unclear. Herein, we evaluate the association of endothelin 2 expression with both clear cell renal cell carcinoma develop... |
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A985G polymorphism of the endothelin-2 gene and atrial fibrillation in patients with hypertrophic cardiomyopathy.
Circ. J. 71(12) , 1932-6, (2007) It was recently suggested that the angiotensin-converting enzyme insertion/insertion genotype, which is considered to be protective against cardiovascular disease, was a significant risk factor for atrial fibrillation (AF) in patients with hypertrophic cardio... |
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Endothelin-2/vasoactive intestinal contractor: regulation of expression via reactive oxygen species induced by CoCl2, and Biological activities including neurite outgrowth in PC12 cells.
ScientificWorldJournal 6 , 176-186, (2006) This paper reviews the local hormone endothelin-2 (ET-2), or vasoactive intestinal contractor (VIC), a member of the vasoconstrictor ET peptide family, where ET-2 is the human orthologous peptide of the murine VIC. While ET-2/VIC gene expression has been obse... |
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Endothelin-2 synthesis is stimulated by the type-1 tumour necrosis factor receptor and cAMP: comparison with endothelin-converting enzyme-1 expression.
J. Mol. Endocrinol. 24 , 273-283, (2000) ABSTRACT The synthesis of the vasoconstrictor peptide endothelin-2 (ET-2) is dependent on hydrolysis of the biologically inactive intermediate big ET-2 by an endothelin-converting enzyme (ECE). Here, mechanisms inducing ET-2 synthesis have been investigated u... |
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Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study.
Biomarkers 21 , 257-66, (2016) There is paucity of information on mechanisms constituting adverse birth outcomes. We assessed here the relationship between vascular integrity and adverse birth effects.Third trimester maternal plasma (n = 144) from the Maternal-Infant Research on Environmen... |