Bioorganic & medicinal chemistry letters

Urea/thiourea catalyzed, solvent-free synthesis of 5-arylidenethiazolidine-2, 4-diones and 5-arylidene-2-thioxothiazolidin-4-ones

S Shah, B Singh

Index: Shah, Sakshi; Singh, Baldev Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 17 p. 5388 - 5391

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Citation Number: 7

Abstract

An efficient and organo-catalyzed method has been developed for the synthesis of 5- arylidenethiazolidine-2, 4-diones and 5-arylidene-2-thioxothiazolidin-4-ones via Knoevenagel condensation of arylaldehydes 1 and 2, 4-thiazolidinedione 2a/2- thioxothiazolidin-4-one 2b under mild conditions. Urea-adduct 4 and azomethine 5 also afford arylidene-products 3 by reacting with 2a–b via addition–elimination reaction. This ...