Electronic Journal of Biotechnology

Peptide synthesis: chemical or enzymatic

F Guzmán, S Barberis, A Illanes

Index: Miyazawa, Toshifumi; Tanaka, Kayoko; Ensatsu, Eiichi; Yanagihara, Ryoji; Yamada, Takashi Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 1 p. 87 - 93

Full Text: HTML

Citation Number: 126

Abstract

... Electronic Journal of Biotechnology ISSN: 0717-3458, Vol. ... Chemically modified peptides with improved bioavailability and metabolic stability may be directly used as drugs and ... Among the technologies available for the large scale synthesis of peptides, chemical synthesis is the ...

 Related Synthetic Route
Dimethylamine hydrochloride Structure

506-59-2

Dimethylamine h...

Chloroacetyl chloride Structure

79-04-9

Chloroacetyl ch...

~32%

2-Chloro-N,N-dimethylacetamide Structure

2675-89-0

2-Chloro-N,N-di...

Z-Gly carbamoylmethyl ester Structure

4816-85-7

Z-Gly carbamoyl...

H-Leu-NH2.HCl Structure

10466-61-2

H-Leu-NH2.HCl

~90%

Z-Gly-Leu-NH2 Structure

7535-72-0

Z-Gly-Leu-NH2

H-Leu-NH2.HCl Structure

10466-61-2

H-Leu-NH2.HCl

N/A Structure

203640-50-0

N/A

~74%

Z-Gly-Leu-NH2 Structure

7535-72-0

Z-Gly-Leu-NH2

N-benzyloxycarbonyl-glycine p-nitrobenzyl ester Structure

5680-81-9

N-benzyloxycarb...

H-Leu-NH2.HCl Structure

10466-61-2

H-Leu-NH2.HCl

~24%

Z-Gly-Leu-NH2 Structure

7535-72-0

Z-Gly-Leu-NH2

Z-Gly-OMe Structure

1212-53-9

Z-Gly-OMe

H-Leu-NH2.HCl Structure

10466-61-2

H-Leu-NH2.HCl

~0%

Z-Gly-Leu-NH2 Structure

7535-72-0

Z-Gly-Leu-NH2

benzyl N-benzyloxycarbonylglycinate Structure

5513-38-2

benzyl N-benzyl...

H-Leu-NH2.HCl Structure

10466-61-2

H-Leu-NH2.HCl

~4%

Z-Gly-Leu-NH2 Structure

7535-72-0

Z-Gly-Leu-NH2

Z-Gly-OH Structure

1138-80-3

Z-Gly-OH

~%

Z-Gly-Leu-NH2 Structure

7535-72-0

Z-Gly-Leu-NH2

N-Cbz-L-Serine Structure

1145-80-8

N-Cbz-L-Serine

~%

N-Benzyloxycarbonylserylleucinamide Structure

17331-87-2

N-Benzyloxycarb...

H-Leu-NH2.HCl Structure

10466-61-2

H-Leu-NH2.HCl

N-(benzyloxycarbonyl)-L-serine p-nitrobenzyl ester Structure

6169-33-1

N-(benzyloxycar...

~91%

N-Benzyloxycarbonylserylleucinamide Structure

17331-87-2

N-Benzyloxycarb...

H-Leu-NH2.HCl Structure

10466-61-2

H-Leu-NH2.HCl

Z-L-Ser-OCam Structure

194658-69-0

Z-L-Ser-OCam

~90%

N-Benzyloxycarbonylserylleucinamide Structure

17331-87-2

N-Benzyloxycarb...

H-Leu-NH2.HCl Structure

10466-61-2

H-Leu-NH2.HCl

N/A Structure

203640-51-1

N/A

~89%

N-Benzyloxycarbonylserylleucinamide Structure

17331-87-2

N-Benzyloxycarb...

N-Carbobenzoxy-L-serine Benzyl Ester Structure

21209-51-8

N-Carbobenzoxy-...

H-Leu-NH2.HCl Structure

10466-61-2

H-Leu-NH2.HCl

~68%

N-Benzyloxycarbonylserylleucinamide Structure

17331-87-2

N-Benzyloxycarb...

N-Cbz-L-serine methyl ester Structure

1676-81-9

N-Cbz-L-serine ...

H-Leu-NH2.HCl Structure

10466-61-2

H-Leu-NH2.HCl

~9%

N-Benzyloxycarbonylserylleucinamide Structure

17331-87-2

N-Benzyloxycarb...

diazomethane Structure

186581-53-3

diazomethane

Z-Val-OH Structure

1149-26-4

Z-Val-OH

~99%

Z-Val-Ome Structure

24210-19-3

Z-Val-Ome


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