Regioselective palladium-catalyzed arylation of 2-furaldehyde

…, B Glover, E McSorley, A Millar, MH Osterhout…

Index: McClure; Glover; McSorley; Millar; Osterhout; Roschangar Organic letters, 2001 , vol. 3, # 11 p. 1677 - 1680

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Citation Number: 122

Abstract

An efficient regioselective method for the direct arylation of 2-furaldehyde to provide a range of π-diverse 5-aryl-2-formylfuran derivatives is described. The method employs functionalized aryl halides and a catalytic amount of palladium (II) chloride under relatively mild conditions.

~73%

~73%

~67%

~87%

~61%

~88%

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A practical one-pot synthesis of 5-aryl-2-furaldehydes

[McClure; Roschangar; Hodson; Millar; Osterhout Synthesis, 2001 , # 11 p. 1681 - 1685]