Organic letters

A Practical and Convenient Protocol for the Synthesis of (E)-α, β-Unsaturated Acids†

AR Mohite, RG Bhat

Index: Mohite, Amar R.; Bhat, Ramakrishna G. Organic Letters, 2013 , vol. 15, # 17 p. 4564 - 4567

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Citation Number: 8

Abstract

α, β-Unsaturated acids are very useful and versatile reagents in organic synthesis. A novel, practical, and convenient catalytic protocol comprising FeCl3· 6H2O (0.5 mol%) and H2O (1 equiv) in CH3NO2 is described for the rapid synthesis of α, β-unsaturated acids with high E- stereoselectivity under both microwave and conventional heating conditions with high TON and TOF values. This powerful approach efficiently demonstrated the utility of biomass ...