Tetrahedron

An efficient α-hydroxylation of carbonyls using the HOF• CH 3 CN complex

S Dayan, Y Bareket, S Rozen

Index: Dayan, Sharon; Bareket, Yifat; Rozen, Shlomo Tetrahedron, 1999 , vol. 55, # 12 p. 3657 - 3664

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Citation Number: 16

Abstract

The complex HOF• CH3CN, made directly from fluorine and aqueous acetonitrile, was used for α-hydroxylation of various ketones, esters and acids via their trimethyl silyl enol ethers. The reaction is usually complete in a few minutes at room temperature or below and has high yields.