Tetrahedron letters

One-pot synthesis of conjugated alkynenitriles from aldehydes

JG Kim, EH Lee, DO Jang

Index: Kim, Joong-Gon; Lee, Eun Hwa; Jang, Doo Ok Tetrahedron Letters, 2007 , vol. 48, # 13 p. 2299 - 2301

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Citation Number: 3

Abstract

A method of preparing conjugated alkynenitriles was developed from various aldehydes with CCl3CN and PPh3 in the presence of tBuLi. The reaction proceeded via α-chlorovinyl nitrile as an intermediate without any side reactions such as chlorination of starting