Tetrahedron Letters

Direct reductive amination of carbonyl compounds with primary/secondary amines using recyclable water-soluble Fe II/EDTA complex as catalyst

…, MJ Bhanushali, NS Nandurkar, BM Bhanage

Index: Bhor, Malhari D.; Bhanushali, Mayur J.; Nandurkar, Nitin S.; Bhanage, Bhalchandra M. Tetrahedron Letters, 2008 , vol. 49, # 6 p. 965 - 969

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Citation Number: 52

Abstract

Direct reductive amination of aliphatic, aromatic and heterocyclic carbonyl compounds with primary/secondary amines is reported with water-soluble FeII/EDTA complex as a catalyst using low-pressure molecular hydrogen in a biphasic media. The catalyst is highly selective, recyclable and is an excellent replacement for expensive noble metal catalysts or stoichiometric reducing agents.