CONFORMATIONAL RIGIDITY INTRODUCED BY 2′, 5′-PHOSPHODIESTER LINKS IN DNA

A Kumar, D Dass, M Atreyi, MVR Rao…

Index: Kumar, Anil; Dass, Debasis; Atreyi; Rao; Katti Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 10-11 p. 1783 - 1796

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Abstract

Conformational properties of 2′, 5′-linked 3′-deoxyribonucleotides have been compared with their natural isomer using CD spectroscopy. It is inferred from the salt induced titration curves that the 2′, 5′-linked-3′ deoxyribonucleotides have rigid phosphodiester backbone.