2-Cyanoethyltetraisopropylphosphorodiamidite

Modify Date: 2024-01-02 17:07:01

2-Cyanoethyltetraisopropylphosphorodiamidite Structure
2-Cyanoethyltetraisopropylphosphorodiamidite structure
Common Name 2-Cyanoethyltetraisopropylphosphorodiamidite
CAS Number 102691-36-1 Molecular Weight 301.408
Density 0.949 g/mL at 25 °C(lit.) Boiling Point 298.1±0.0 °C at 760 mmHg
Molecular Formula C15H32N3OP Melting Point N/A
MSDS Chinese USA Flash Point 177.9±28.4 °C
Symbol GHS02 GHS08
GHS02, GHS08
Signal Word Danger

 Names

Name Bis(Diisopropylamino)(2-Cyanoethoxy)Phosphine
Synonym More Synonyms

 Chemical & Physical Properties

Density 0.949 g/mL at 25 °C(lit.)
Boiling Point 298.1±0.0 °C at 760 mmHg
Molecular Formula C15H32N3OP
Molecular Weight 301.408
Flash Point 177.9±28.4 °C
Exact Mass 301.228302
PSA 53.09000
LogP 4.00
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction n20/D 1.470(lit.)
Storage condition 2-8°C
Stability Explodes When Heated

 Safety Information

Symbol GHS02 GHS08
GHS02, GHS08
Signal Word Danger
Hazard Statements H226-H315-H317-H319-H334
Precautionary Statements P261-P280-P305 + P351 + P338-P342 + P311
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R5;R36/37/38
Safety Phrases S3-S26-S36
RIDADR UN 1993 3/PG 3
WGK Germany 3
Packaging Group I
Hazard Class 8
HS Code 2926909090

 Synthetic Route

~91%

2-Cyanoethyltetraisopropylphosphorodiamidite Structure

2-Cyanoethyltet...

CAS#:102691-36-1

Literature: WO2003/106468 A1, ; Page 6-7 ;

~40%

2-Cyanoethyltetraisopropylphosphorodiamidite Structure

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CAS#:102691-36-1

Literature: Monatshefte fur Chemie, , vol. 141, # 7 p. 809 - 815

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2-Cyanoethyltetraisopropylphosphorodiamidite Structure

2-Cyanoethyltet...

CAS#:102691-36-1

Literature: Chemistry Letters, , p. 1401 - 1404

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2-Cyanoethyltetraisopropylphosphorodiamidite Structure

2-Cyanoethyltet...

CAS#:102691-36-1

Literature: Chemistry Letters, , p. 1401 - 1404

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2-Cyanoethyltetraisopropylphosphorodiamidite Structure

2-Cyanoethyltet...

CAS#:102691-36-1

Literature: Tetrahedron, , vol. 46, # 2 p. 487 - 502

 Customs

HS Code 2926909090
Summary HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Articles8

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The synthesis of oligonucleotides containing 2'-deoxy-2'-fluoro-4'-thioarabinonucleotides is described. 2'-Deoxy-2'-fluoro-5-methyl-4'-thioarabinouridine (4'S-FMAU) was incorporated into 18-mer antise...

DNA adducts of acrolein: site-specific synthesis of an oligodeoxynucleotide containing 6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a]purin-10(3H)-one, an acrolein adduct of guanine.

Chem. Res. Toxicol. 15(5) , 607-13, (2002)

3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a]purin-10(3H)-one is formed in low yield by the reaction of acrolein with 2'-deoxyguanosine. The nucleoside and an o...

Synthesis and fluorescence studies of multiple labeled oligonucleotides containing dansyl fluorophore covalently attached at 2'-terminus of cytidine via carbamate linkage.

Bioconjug. Chem. 15 , 638-646, (2004)

Synthesis of modified oligonucleotides in which the specific cytidine nucleoside analogues linked at 2'-OH position via a carbamate bond with an amino ethyl derivative of dansyl fluorophore is reporte...

 Synonyms

3-bis[di(propan-2-yl)amino]phosphanyloxypropanenitrile
2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite
2-cyanoethyl N,N,N',N'-tetrapropan-2-ylphosphorodiamidoite
2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidoite
2-Cyanoethyl N,N,N,N-tetraisopropylphosphordiamidite
2-Cyanoethyl N,N,N′,N′-tetraisopropylphosphordiamidite
Phosphorodiamidous acid, N,N,N',N'-tetrakis(1-methylethyl)-, 2-cyanoethyl ester
Phosphorodiamidous acid, tetrakis(1-methylethyl)-, 2-cyanoethyl ester
Bis(diisopropylamino)(2-cyanoethoxy)phosphine
MFCD00012213
2-Cyanoethyl N,N,N',N'-tetraisopropyldiamidophosphite
2-Cyanoethyl N,N,N',N'-tetraisopropylphosphordiamidite
3-((Bis(diisopropylamino)phosphino)oxy)propanenitrile
2-Cyanoethyltetraisopropylphosphorodiamidite
2-Cyanoethyl-N,N,N',N'-tetraisopropylphosphorodiamidite
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