e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Organometallics

Utility of dysprosium as a reductant in coupling reactions of acyl chlorides: the synthesis of amides and diaryl-substituted acetylenes

W Chen, K Li, Z Hu, L Wang, G Lai, Z Li

Index: Chen, Weifeng; Li, Kebin; Hu, Ziqiang; Wang, Liliang; Lai, Guoqiao; Li, Zhifang Organometallics, 2011 , vol. 30, # 7 p. 2026 - 2030

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Citation Number: 9

Abstract

Reduction of acyl chlorides with dysprosium metal has been studied. The reducing ability of dysprosium metal is solvent-dependent. Dysprosium metal, which requires neither any additive nor pretreatment, can promote the cross-coupling of acyl chlorides in DMF or DEF to give amides in good yields. When the reaction was performed in N, N-dimethylacetamide, the reductive self-coupling reaction of aroyl chloride took place smoothly and afforded the ...

Diethylformamide Structure

Diethylformamide

3-Chlorobenzoyl chloride Structure

3-Chlorobenzoyl...

~90%

3-chloro-N,N-diethylbenzamide Structure

3-chloro-N,N-di...

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

Heptanoyl chloride Structure

Heptanoyl chloride

~64%

N,N-DIMETHYLPIMELAMIDE Structure

N,N-DIMETHYLPIM...

O-Toluoylchloride Structure

O-Toluoylchloride

~87%

1-methyl-2-[2-(2-methylphenyl)ethynyl]benzene Structure

1-methyl-2-[2-(...

p-toluoyl chloride Structure

p-toluoyl chloride

~82%

DI-P-TOLYLACETYLENE Structure

DI-P-TOLYLACETYLENE

3-Chlorobenzoyl chloride Structure

3-Chlorobenzoyl...

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

~91%

3-chloro-N,N-dimethylbenzamide Structure

3-chloro-N,N-di...

Diethylformamide Structure

Diethylformamide

Benzoyl chloride Structure

Benzoyl chloride

~80%

N,N-DIETHYLBENZAMIDE Structure

N,N-DIETHYLBENZAMIDE

1-Naphthoyl chloride Structure

1-Naphthoyl chloride

~38%

Ethanedione,di-1-naphthalenyl- Structure

Ethanedione,di-...

Dinaphthylacetylene Structure

Dinaphthylacetylene

4-Ethylbenzoyl chloride Structure

4-Ethylbenzoyl ...

~70%

1,1'-(1,2-Ethynediyl)bis(4-ethylbenzene) Structure

1,1'-(1,2-Ethyn...

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

2-naphthoic chloride Structure

2-naphthoic chloride

~86%

N,N-dimethylnaphthalene-2-carboxamide Structure

N,N-dimethylnap...

Benzoyl chloride Structure

Benzoyl chloride

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

~91%

1N1&VR Structure

p-toluoyl chloride Structure

p-toluoyl chloride

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

~89%

Benzamide,N,N,4-trimethyl- Structure

Benzamide,N,N,4...

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

Phenylacetyl chloride Structure

Phenylacetyl ch...

~82%

Benzeneacetamide,N,N-dimethyl- Structure

Benzeneacetamid...

p-Anisoyl chloride Structure

p-Anisoyl chloride

~59%

1-methoxy-4-[2-(4-methoxyphenyl)ethynyl]benzene Structure

1-methoxy-4-[2-...

Benzoyl chloride Structure

Benzoyl chloride

N-Methylformanilide Structure

N-Methylformanilide

~85%

Benzamide,N-methyl-N-phenyl- Structure

Benzamide,N-met...

4-Chlorobenzoyl chloride Structure

4-Chlorobenzoyl...

~30%

Benzene, 1,1-(1,2-ethynediyl)bis(4-chloro- Structure

Benzene, 1,1-(1...

4,4'-Dichloro benzil Structure

4,4'-Dichloro benzil

Benzil Structure

~54%

Diphenylacetylene Structure

Diphenylacetylene

Benzoyl chloride Structure

Benzoyl chloride

~84%

Diphenylacetylene Structure

Diphenylacetylene