Arylalkyl Ketones, Benzophenones, Desoxybenzoins and Chalcones Inhibit TNF?螃? Induced Expression of ICAM??1: Structure??Activity Analysis

S Kumar, L Reddy, C Shekhar, Y Kumar…

Index: Kumar, Sarvesh; Reddy L, Chandra Shekhar; Kumar, Yogesh; Kumar, Amit; Singh, Brajendra K.; Kumar, Vineet; Malhotra, Shashwat; Pandey, Mukesh K.; Jain, Rajni; Thimmulappa, Rajesh; Sharma, Sunil K.; Prasad, Ashok K.; Biswal, Shyam; Van Der Eycken, Erik; Depass, Anthony L.; Malhotra, Sanjay V.; Ghosh, Balaram; Parmar, Virinder S. Archiv der Pharmazie, 2012 , vol. 345, # 5 p. 368 - 377

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Citation Number: 6

Abstract

Abstract The interaction between leukocytes and the vascular endothelial cells (EC) via cellular adhesion molecules plays an important role in the pathogenesis of various inflammatory and autoimmune diseases. Small molecules that block these interactions have been targeted as potential therapeutic agents against acute and chronic inflammatory diseases. In an effort to identify potent intercellular cell adhesion molecule-1 (ICAM-1) ...

 Related Synthetic Route
Benzoyl chloride Structure

98-88-4

Benzoyl chloride

Resorcine Structure

108-46-3

Resorcine

~%

(2,6-dihydroxyphenyl)-phenylmethanone Structure

63411-81-4

(2,6-dihydroxyp...

3,4-Dimethoxyphenylacetic acid Structure

93-40-3

3,4-Dimethoxyph...

Phloroglucinol Structure

108-73-6

Phloroglucinol

~%

2-(3,4-dimethoxyphenyl)-1-(2,4,6-trihydroxyphenyl)ethan-1-one Structure

53084-06-3

2-(3,4-dimethox...

3,5-Dimethoxyphenol Structure

500-99-2

3,5-Dimethoxyphenol

acetic acid Structure

64-19-7

acetic acid

~81%

Xanthoxylin Structure

90-24-4

Xanthoxylin

Phloroglucinol Structure

108-73-6

Phloroglucinol

acetic acid Structure

64-19-7

acetic acid

~77%

2',4',6'-Trihydroxyacetophenone Monohydrate Structure

480-66-0

2',4',6'-Trihyd...

Phloroglucinol Structure

108-73-6

Phloroglucinol

(2,4-Dimethoxyphenyl)acetic acid Structure

6496-89-5

(2,4-Dimethoxyp...

~%

2-(2,4-dimethoxyphenyl)-1-(2,4,6-trihydroxyphenyl)ethanone Structure

65568-08-3

2-(2,4-dimethox...

Phenylacetic acid Structure

103-82-2

Phenylacetic acid

1,3-Diacetoxybenzene Structure

108-58-7

1,3-Diacetoxybenzene

~%

[3-acetyloxy-4-(2-phenylacetyl)phenyl] acetate Structure

22665-91-4

[3-acetyloxy-4-...

4-Methoxybenzaldehyde Structure

123-11-5

4-Methoxybenzal...

~%

Benzenepropanol,4-methoxy-a-phenyl- Structure

10496-72-7

Benzenepropanol...

Acetophenone Structure

98-86-2

Acetophenone

~%

Benzenepropanol,4-methoxy-a-phenyl- Structure

10496-72-7

Benzenepropanol...

(E)-4,4'-(prop-1-ene-1,3-diyl)bis(methoxybenzene) Structure

34414-53-4

(E)-4,4'-(prop-...

~%

1-methoxy-4-[3-(4-methoxyphenyl)propyl]benzene Structure

4741-73-5

1-methoxy-4-[3-...

1,3-bis(4-methoxyphenyl)propan-1-one Structure

20615-47-8

1,3-bis(4-metho...

~%

1-methoxy-4-[3-(4-methoxyphenyl)propyl]benzene Structure

4741-73-5

1-methoxy-4-[3-...

4-Methoxybenzaldehyde Structure

123-11-5

4-Methoxybenzal...

~%

1-methoxy-4-[3-(4-methoxyphenyl)propyl]benzene Structure

4741-73-5

1-methoxy-4-[3-...

Acetanisole Structure

100-06-1

Acetanisole

~%

1-methoxy-4-[3-(4-methoxyphenyl)propyl]benzene Structure

4741-73-5

1-methoxy-4-[3-...

2,5-dihydroxy-4-methoxybenzoyl chloride Structure

1378871-36-3

2,5-dihydroxy-4...

benzene Structure

71-43-2

benzene

~%

Cearoin Structure

52811-37-7

Cearoin

N/A Structure

802294-64-0

N/A

Resorcine Structure

108-46-3

Resorcine

~80%

2',4'-Dihydroxypropiophenone Structure

5792-36-9

2',4'-Dihydroxy...

(E)-1-methoxy-4-(3-phenyl-1-propen-1-yl)benzene Structure

35856-81-6

(E)-1-methoxy-4...

~%

1-methoxy-4-(3-phenylpropyl)benzene Structure

40715-68-2

1-methoxy-4-(3-...

1-(4-methoxy-phenyl)-3-phenylpropan-1-ol Structure

24788-17-8

1-(4-methoxy-ph...

~%

1-methoxy-4-(3-phenylpropyl)benzene Structure

40715-68-2

1-methoxy-4-(3-...

Benzenepropanol,4-methoxy-a-phenyl- Structure

10496-72-7

Benzenepropanol...

~%

1-methoxy-4-(3-phenylpropyl)benzene Structure

40715-68-2

1-methoxy-4-(3-...

4-Methoxybenzaldehyde Structure

123-11-5

4-Methoxybenzal...

~%

1-methoxy-4-(3-phenylpropyl)benzene Structure

40715-68-2

1-methoxy-4-(3-...

Acetophenone Structure

98-86-2

Acetophenone

~%

1-methoxy-4-(3-phenylpropyl)benzene Structure

40715-68-2

1-methoxy-4-(3-...

1-Methoxy-4-[(E)-3-phenylallyl]benzene Structure

35856-80-5

1-Methoxy-4-[(E...

~%

1-methoxy-4-(3-phenylpropyl)benzene Structure

40715-68-2

1-methoxy-4-(3-...

1-(4-methoxyphenyl)-3-phenyl-propan-1-one Structure

5739-38-8

1-(4-methoxyphe...

~%

1-methoxy-4-(3-phenylpropyl)benzene Structure

40715-68-2

1-methoxy-4-(3-...

1-Propanone,3-(4-methoxyphenyl)-1-phenyl- Structure

1669-49-4

1-Propanone,3-(...

~%

1-methoxy-4-(3-phenylpropyl)benzene Structure

40715-68-2

1-methoxy-4-(3-...

Benzaldehyde Structure

100-52-7

Benzaldehyde

~%

1-methoxy-4-(3-phenylpropyl)benzene Structure

40715-68-2

1-methoxy-4-(3-...

Acetanisole Structure

100-06-1

Acetanisole

~%

1-methoxy-4-(3-phenylpropyl)benzene Structure

40715-68-2

1-methoxy-4-(3-...

m-Methoxyphenol Structure

150-19-6

m-Methoxyphenol

acetic acid Structure

64-19-7

acetic acid

~79%

Paeonol Structure

552-41-0

Paeonol


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