Synthesis and biological evaluation of new 2-(4, 5-dihydro-1 H-imidazol-2-yl)-3, 4-dihydro-2 H-1, 4-benzoxazine derivatives

F Touzeau, A Arrault, G Guillaumet…

Index: Touzeau, Frederique; Arrault, Axelle; Guillaumet, Gerald; Scalbert, Elizabeth; Pfeiffer, Bruno; Rettori, Marie-Claire; Renard, Pierre; Merour, Jean-Yves Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1962 - 1979

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Citation Number: 81

Abstract

2-(4, 5-Dihydro-1 H-imidazol-2-yl)-3, 4-dihydro-2 H-1, 4-benzoxazine derivatives and tricyclic analogues with a fused additional ring on the nitrogen atom of the benzoxazine moiety have been prepared and evaluated for their cardiovascular effects as potential antihypertensive agents. The imidazoline ring was generated by reaction of the corresponding ethyl ester with ethylenediamine. Affinities for imidazoline binding sites ( ...