e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

6-(Alkylamino)-3-aryl-1, 2, 4-triazolo [3, 4-a] phthalazines. A new class of benzodiazepine receptor ligands

…, E Occelli, E Toja, D Barone, N Corsico…

Index: Tarzia, Giorgio; Occelli, Emilio; Toja, Emilio; Barone, Domenico; Corsico, Nerina; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1115 - 1123

Full Text: HTML

Citation Number: 55

Abstract

Some 6-(alkylamino)-3-aryl-1, 2, 4-triazolo [3, 4-a] phthalazines have been shown to displace diazepam from rat brain specific binding sites, in vitro, with Ki (nM) values comparable to those of reference benzodiazepines and to have anticonvulsant (pentylenetetrazole test, mice) and anticonflict activity (Vogel test, rat) in vivo. Separation between the doses causing anticonflict effects (Vogel test, rat) and those impairing motor ...

Pyrrolidine Structure

6-Chloro-3-(4-methoxyphenyl)[1,2,4]triazolo[3,4-a]phthalazine Structure

6-Chloro-3-(4-m...

~94%

3-(4-methoxyphenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(4-methoxyphe...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

3-(4-methoxyphenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(4-methoxyphe...

p-Anisoyl chloride Structure

p-Anisoyl chloride

~%

3-(4-methoxyphenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(4-methoxyphe...

Pyrrolidine Structure

6-chloro-3-(3-methoxy-4-(pentyloxy)phenyl)-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-(3-m...

~91%

3-(3-methoxy-4-pentoxyphenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(3-methoxy-4-...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

3-(3-methoxy-4-pentoxyphenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(3-methoxy-4-...

4-n-pentyloxy-3-methoxybenzoic acid Structure

4-n-pentyloxy-3...

~%

3-(3-methoxy-4-pentoxyphenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(3-methoxy-4-...

3-methoxy-4-(pentyloxy)benzoyl chloride Structure

3-methoxy-4-(pe...

~%

3-(3-methoxy-4-pentoxyphenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(3-methoxy-4-...

Pyrrolidine Structure

6-chloro-3-(4-chloro-3-nitrophenyl)-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-(4-c...

~54%

3-(4-chloro-3-nitrophenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(4-chloro-3-n...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

3-(4-chloro-3-nitrophenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(4-chloro-3-n...

4-Chloro-3-nitrobenzoyl chloride Structure

4-Chloro-3-nitr...

~%

3-(4-chloro-3-nitrophenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(4-chloro-3-n...

Pyrrolidine Structure

6-chloro-3-(2-bromo-phenyl)-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-(2-b...

~88%

3-(2-bromophenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(2-bromopheny...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

3-(2-bromophenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(2-bromopheny...

2-Bromobenzoyl chloride Structure

2-Bromobenzoyl ...

~%

3-(2-bromophenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(2-bromopheny...

Pyrrolidine Structure

3-([1,1'-biphenyl]-4-yl)-6-chloro-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-([1,1'-biphen...

~77%

s-Triazolo(3,4-a)phthalazine, 3-(1,1'-biphenyl-4-yl)-6-(1-pyrrolidinyl)- Structure

s-Triazolo(3,4-...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

s-Triazolo(3,4-a)phthalazine, 3-(1,1'-biphenyl-4-yl)-6-(1-pyrrolidinyl)- Structure

s-Triazolo(3,4-...

4-Biphenylcarbaldehyde Structure

4-Biphenylcarba...

~%

s-Triazolo(3,4-a)phthalazine, 3-(1,1'-biphenyl-4-yl)-6-(1-pyrrolidinyl)- Structure

s-Triazolo(3,4-...

1-(2-([1,1'-biphenyl]-4-ylmethylene)hydrazinyl)-4-chlorophthalazine Structure

1-(2-([1,1'-bip...

~%

s-Triazolo(3,4-a)phthalazine, 3-(1,1'-biphenyl-4-yl)-6-(1-pyrrolidinyl)- Structure

s-Triazolo(3,4-...

Pyrrolidine Structure

4-(6-chloro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzonitrile Structure

4-(6-chloro-[1,...

~58%

4-(7-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzonitrile Structure

4-(7-pyrrolidin...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

4-(7-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzonitrile Structure

4-(7-pyrrolidin...

4-Cyanobenzoyl chloride Structure

4-Cyanobenzoyl ...

~%

4-(7-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzonitrile Structure

4-(7-pyrrolidin...

Pyrrolidine Structure

N/A Structure

~78%

1,2,4-Triazolo(3,4-a)phthalazine, 6-(1-pyrrolidinyl)-3-(2,4,5-triethox yphenyl)- Structure

1,2,4-Triazolo(...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

1,2,4-Triazolo(3,4-a)phthalazine, 6-(1-pyrrolidinyl)-3-(2,4,5-triethox yphenyl)- Structure

1,2,4-Triazolo(...

2,4,5-TRIETHOXY BENZALDEHYDE Structure

2,4,5-TRIETHOXY...

~%

1,2,4-Triazolo(3,4-a)phthalazine, 6-(1-pyrrolidinyl)-3-(2,4,5-triethox yphenyl)- Structure

1,2,4-Triazolo(...

1-chloro-4-(2-(2,4,5-triethoxybenzylidene)hydrazinyl)phthalazine Structure

1-chloro-4-(2-(...

~%

1,2,4-Triazolo(3,4-a)phthalazine, 6-(1-pyrrolidinyl)-3-(2,4,5-triethox yphenyl)- Structure

1,2,4-Triazolo(...

Bis(2-methoxyethyl)amine Structure

Bis(2-methoxyet...

N/A Structure

~79%

N,N-bis(2-methoxyethyl)-3-(4-propan-2-yloxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N,N-bis(2-metho...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

N,N-bis(2-methoxyethyl)-3-(4-propan-2-yloxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N,N-bis(2-metho...

4-isopropoxybenzoyl chloride Structure

4-isopropoxyben...

~%

N,N-bis(2-methoxyethyl)-3-(4-propan-2-yloxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N,N-bis(2-metho...

Pyrrolidine Structure

N-(4-(6-chloro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)phenyl)acetamide Structure

N-(4-(6-chloro-...

~89%

N-[4-(6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)phenyl]acetamide Structure

N-[4-(6-pyrroli...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

N-[4-(6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)phenyl]acetamide Structure

N-[4-(6-pyrroli...

4-Acetamidobenzaldehyde Structure

4-Acetamidobenz...

~%

N-[4-(6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)phenyl]acetamide Structure

N-[4-(6-pyrroli...

N-(4-((2-(4-chlorophthalazin-1-yl)hydrazono)methyl)phenyl)acetamide Structure

N-(4-((2-(4-chl...

~%

N-[4-(6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)phenyl]acetamide Structure

N-[4-(6-pyrroli...

Pyrrolidine Structure

6-chloro-3-(3,5-dibromo-2-ethoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-(3,5...

~90%

1,2,4-Triazolo(3,4-a)phthalazine, 3-(3,5-dibromo-2-ethoxyphenyl)-6-(1- pyrrolidinyl)- Structure

1,2,4-Triazolo(...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

1,2,4-Triazolo(3,4-a)phthalazine, 3-(3,5-dibromo-2-ethoxyphenyl)-6-(1- pyrrolidinyl)- Structure

1,2,4-Triazolo(...

Benzaldehyde,3,5-dibromo-2-ethoxy- Structure

Benzaldehyde,3,...

~%

1,2,4-Triazolo(3,4-a)phthalazine, 3-(3,5-dibromo-2-ethoxyphenyl)-6-(1- pyrrolidinyl)- Structure

1,2,4-Triazolo(...

1-chloro-4-(2-(3,5-dibromo-2-ethoxybenzylidene)hydrazinyl)phthalazine Structure

1-chloro-4-(2-(...

~%

1,2,4-Triazolo(3,4-a)phthalazine, 3-(3,5-dibromo-2-ethoxyphenyl)-6-(1- pyrrolidinyl)- Structure

1,2,4-Triazolo(...

Pyrrolidine Structure

3-(3-bromo-4,5-dimethoxyphenyl)-6-chloro-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(3-bromo-4,5-...

~57%

3-(3-bromo-4,5-dimethoxyphenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(3-bromo-4,5-...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

3-(3-bromo-4,5-dimethoxyphenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(3-bromo-4,5-...

3-Bromo-4,5-dimethoxybenzaldehyde Structure

3-Bromo-4,5-dim...

~%

3-(3-bromo-4,5-dimethoxyphenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(3-bromo-4,5-...

1-(2-(3-bromo-4,5-dimethoxybenzylidene)hydrazinyl)-4-chlorophthalazine Structure

1-(2-(3-bromo-4...

~%

3-(3-bromo-4,5-dimethoxyphenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(3-bromo-4,5-...

Pyrrolidine Structure

3-Chlorobenzoyl chloride Structure

3-Chlorobenzoyl...

~86%

6-pyrrolidin-1-yl-3-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-pyrrolidin-1-...

6-chloro-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-phen...

n-butylamine Structure

~74%

N-butyl-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N-butyl-3-pheny...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

N-butyl-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N-butyl-3-pheny...

Benzaldehyde Structure

~%

N-butyl-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N-butyl-3-pheny...

N-(benzylideneamino)-4-chlorophthalazin-1-amine Structure

N-(benzylidenea...

~%

N-butyl-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N-butyl-3-pheny...

Bis(2-methoxyethyl)amine Structure

Bis(2-methoxyet...

6-chloro-3-(4-fluorophenyl)-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-(4-f...

~82%

3-(4-fluorophenyl)-N,N-bis(2-methoxyethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

3-(4-fluorophen...

4-FLUOROBENZOYL CHLORIDE Structure

4-FLUOROBENZOYL...

~%

3-(4-fluorophenyl)-N,N-bis(2-methoxyethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

3-(4-fluorophen...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

3-phenyl-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-phenyl-6-pyrr...

Benzaldehyde Structure

~%

3-phenyl-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-phenyl-6-pyrr...

N-(benzylideneamino)-4-chlorophthalazin-1-amine Structure

N-(benzylidenea...

~%

3-phenyl-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-phenyl-6-pyrr...

morpholine Structure

6-chloro-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-phen...

~67%

4-(3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)morpholine Structure

4-(3-phenyl-[1,...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

4-(3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)morpholine Structure

4-(3-phenyl-[1,...

Benzaldehyde Structure

~%

4-(3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)morpholine Structure

4-(3-phenyl-[1,...

N-(benzylideneamino)-4-chlorophthalazin-1-amine Structure

N-(benzylidenea...

~%

4-(3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)morpholine Structure

4-(3-phenyl-[1,...

Pyrrolidine Structure

4-(6-chloro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzamide Structure

4-(6-chloro-[1,...

~58%

4-(7-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzamide Structure

4-(7-pyrrolidin...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

4-(7-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzamide Structure

4-(7-pyrrolidin...

4-ACETAMINOBENZALDEHYDE Structure

4-ACETAMINOBENZ...

~%

4-(7-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzamide Structure

4-(7-pyrrolidin...

4-((2-(4-chlorophthalazin-1-yl)hydrazono)methyl)benzamide Structure

4-((2-(4-chloro...

~%

4-(7-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)benzamide Structure

4-(7-pyrrolidin...

N-(benzylideneamino)-4-chlorophthalazin-1-amine Structure

N-(benzylidenea...

~72%

6-chloro-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-phen...

Benzaldehyde Structure

~%

6-chloro-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-phen...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

3-(4-fluorophenyl)-N,N-bis(2-methoxyethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

3-(4-fluorophen...

Bis(2-methoxyethyl)amine Structure

Bis(2-methoxyet...

4-(6-chloro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)phenol Structure

4-(6-chloro-[1,...

~70%

4-[6-[bis(2-methoxyethyl)amino]-2H-[1,2,4]triazolo[3,4-a]phthalazin-3-ylidene]cyclohexa-2,5-dien-1-one Structure

4-[6-[bis(2-met...

4-Acetoxy-benzoylchloride Structure

4-Acetoxy-benzo...

~%

4-[6-[bis(2-methoxyethyl)amino]-2H-[1,2,4]triazolo[3,4-a]phthalazin-3-ylidene]cyclohexa-2,5-dien-1-one Structure

4-[6-[bis(2-met...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

4-[6-[bis(2-methoxyethyl)amino]-2H-[1,2,4]triazolo[3,4-a]phthalazin-3-ylidene]cyclohexa-2,5-dien-1-one Structure

4-[6-[bis(2-met...

6-Chloro-3-(4-methoxyphenyl)[1,2,4]triazolo[3,4-a]phthalazine Structure

6-Chloro-3-(4-m...

2-Methoxyethanamine Structure

2-Methoxyethanamine

~87%

N-(2-methoxyethyl)-3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N-(2-methoxyeth...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

N-(2-methoxyethyl)-3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N-(2-methoxyeth...

p-Anisoyl chloride Structure

p-Anisoyl chloride

~%

N-(2-methoxyethyl)-3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N-(2-methoxyeth...

6-chloro-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-phen...

methylamine Structure

~73%

N-methyl-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N-methyl-3-phen...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

N-methyl-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N-methyl-3-phen...

Benzaldehyde Structure

~%

N-methyl-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N-methyl-3-phen...

N-(benzylideneamino)-4-chlorophthalazin-1-amine Structure

N-(benzylidenea...

~%

N-methyl-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N-methyl-3-phen...

Bis(2-methoxyethyl)amine Structure

Bis(2-methoxyet...

6-chloro-3-(3-chlorophenyl)-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-(3-c...

~79%

3-(3-chlorophenyl)-N,N-bis(2-methoxyethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

3-(3-chlorophen...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

3-(3-chlorophenyl)-N,N-bis(2-methoxyethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

3-(3-chlorophen...

3-Chlorobenzoyl chloride Structure

3-Chlorobenzoyl...

~%

3-(3-chlorophenyl)-N,N-bis(2-methoxyethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

3-(3-chlorophen...

Bis(2-methoxyethyl)amine Structure

Bis(2-methoxyet...

6-chloro-3-(m-tolyl)-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-(m-t...

~78%

N,N-bis(2-methoxyethyl)-3-(3-methylphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N,N-bis(2-metho...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

N,N-bis(2-methoxyethyl)-3-(3-methylphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N,N-bis(2-metho...

1-chloro-4-(2-(3-methylbenzylidene)hydrazinyl)phthalazine Structure

1-chloro-4-(2-(...

~%

N,N-bis(2-methoxyethyl)-3-(3-methylphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N,N-bis(2-metho...

m-Tolualdehyde Structure

~%

N,N-bis(2-methoxyethyl)-3-(3-methylphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N,N-bis(2-metho...

6-chloro-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-phen...

Benzylamine Structure

~88%

N-benzyl-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N-benzyl-3-phen...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

N-benzyl-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N-benzyl-3-phen...

Benzaldehyde Structure

~%

N-benzyl-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N-benzyl-3-phen...

N-(benzylideneamino)-4-chlorophthalazin-1-amine Structure

N-(benzylidenea...

~%

N-benzyl-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N-benzyl-3-phen...

6-chloro-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-phen...

Dimethylamine Structure

~85%

N,N-dimethyl-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N,N-dimethyl-3-...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

N,N-dimethyl-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N,N-dimethyl-3-...

Benzaldehyde Structure

~%

N,N-dimethyl-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N,N-dimethyl-3-...

N-(benzylideneamino)-4-chlorophthalazin-1-amine Structure

N-(benzylidenea...

~%

N,N-dimethyl-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-amine Structure

N,N-dimethyl-3-...

Piperidine Structure

6-chloro-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-phen...

~68%

3-phenyl-6-piperidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-phenyl-6-pipe...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

3-phenyl-6-piperidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-phenyl-6-pipe...

Benzaldehyde Structure

~%

3-phenyl-6-piperidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-phenyl-6-pipe...

N-(benzylideneamino)-4-chlorophthalazin-1-amine Structure

N-(benzylidenea...

~%

3-phenyl-6-piperidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-phenyl-6-pipe...

methylpiperazine Structure

methylpiperazine

6-chloro-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-phen...

~81%

6-(4-methylpiperazin-1-yl)-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-(4-methylpipe...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

6-(4-methylpiperazin-1-yl)-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-(4-methylpipe...

Benzaldehyde Structure

~%

6-(4-methylpiperazin-1-yl)-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-(4-methylpipe...

N-(benzylideneamino)-4-chlorophthalazin-1-amine Structure

N-(benzylidenea...

~%

6-(4-methylpiperazin-1-yl)-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-(4-methylpipe...

Pyrrolidine Structure

6-chloro-3-(3,4-dimethylphenyl)-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-(3,4...

~90%

3-(3,4-dimethylphenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(3,4-dimethyl...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

3-(3,4-dimethylphenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(3,4-dimethyl...

3,4-dimethylbenzene-1-carbonyl chloride Structure

3,4-dimethylben...

~%

3-(3,4-dimethylphenyl)-6-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine Structure

3-(3,4-dimethyl...

Pyrrolidine Structure

6-chloro-3-(3,4-dimethoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-(3,4...

~84%

3-(3,4-Dimethoxyphenyl)-6-(1-pyrrolidinyl)-1,2,4-triazolo(3,4-a)phthal azine Structure

3-(3,4-Dimethox...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

~%

3-(3,4-Dimethoxyphenyl)-6-(1-pyrrolidinyl)-1,2,4-triazolo(3,4-a)phthal azine Structure

3-(3,4-Dimethox...

veratroyl chloride Structure

veratroyl chloride

~%

3-(3,4-Dimethoxyphenyl)-6-(1-pyrrolidinyl)-1,2,4-triazolo(3,4-a)phthal azine Structure

3-(3,4-Dimethox...

1-Chloro-4-hydrazinophthalazine Structure

1-Chloro-4-hydr...

4-Chlorobenzoyl chloride Structure

4-Chlorobenzoyl...

~76%

6-chloro-3-(4-chlorophenyl)-[1,2,4]triazolo[3,4-a]phthalazine Structure

6-chloro-3-(4-c...