3-Mercapto-1, 2, 4-triazoles and N-acylated thiosemicarbazides as metallo-β-lactamase inhibitors

…, NU Islam, DL Ollis, G Schenk, RP McGeary

Index: Faridoon; Hussein, Waleed M.; Vella, Peter; Islam, Nazar Ul; Ollis, David L.; Schenk, Gerhard; McGeary, Ross P. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 380 - 386

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Citation Number: 31

Abstract

The production of β-lactamases is an effective strategy by which pathogenic bacteria can develop resistance against β-lactam antibiotics. While inhibitors of serine-β-lactamases are widely used in combination therapy with β-lactam antibiotics, there are no clinically available inhibitors of metallo-β-lactamases (MBLs), and so there is a need for the development of such inhibitors. This work describes the optimisation of a lead inhibitor previously ...