Tetrahedron

Selective and efficient oxidative modifications of flavonoids with 2-iodoxybenzoic acid (IBX)

M Barontini, R Bernini, F Crisante, G Fabrizi

Index: Barontini, Maurizio; Bernini, Roberta; Crisante, Fernanda; Fabrizi, Giancarlo Tetrahedron, 2010 , vol. 66, # 32 p. 6047 - 6053

Full Text: HTML

Citation Number: 30

Abstract

2-Iodoxybenzoic acid (IBX), a mild and efficient hypervalent iodine oxidant, has been utilised in different reaction conditions to perform several efficient oxidative modifications of flavonoids. Fine-tuning of the reaction conditions allowed remarkably selective modifications of these compounds. At room temperature, IBX proved to be an excellent reagent for a highly regioselective aromatic hydroxylation of monohydroxylated flavanones and flavones, ...