CP-471474
Modify Date: 2025-08-29 22:05:41
CP-471474 structure
|
Common Name | CP-471474 | ||
|---|---|---|---|---|
| CAS Number | 210755-45-6 | Molecular Weight | 368.38000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H17FN2O5S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of CP-471474CP-471474 is an orally active and pan MMP inhibitor, with IC50 values of 1170 nM (MMP-1), 0.7 nM (MMP-2), 16 nM (MMP-3), 13 nM (MMP-9) and 0.9 nM (MMP-13), respectively[1][2]. |
| Name | 2-[[4-(4-fluorophenoxy)phenyl]sulfonylamino]-N-hydroxy-2-methylpropanamide |
|---|---|
| Synonym | More Synonyms |
| Description | CP-471474 is an orally active and pan MMP inhibitor, with IC50 values of 1170 nM (MMP-1), 0.7 nM (MMP-2), 16 nM (MMP-3), 13 nM (MMP-9) and 0.9 nM (MMP-13), respectively[1][2]. |
|---|---|
| Related Catalog | |
| Target |
MMP-2:0.7 nM (IC50) MMP-13:0.9 nM (IC50) MMP-9:13 nM (IC50) MMP-3:16 nM (IC50) MMP-1:1170 nM (IC50) |
| In Vivo | CP-471474 plasma levels following subcutaneous injection are 2,020 ng/mL (1 h postdose) to 160 ng/mL (6 h postdose)[2]. CP-471,474 significantly reduces both the extent and severity of inflammation at 2 months. At 4 months, a spontaneous reduction of the inflammatory response is observed in both treated and untreated animals, and consequently no difference is observed between both[2]. CP-471474 significantly decreases the destructive lesions mainly at 2 months and also at 4 months[2]. Animal Model: Guinea pigs weighing 400 to 450 g (COPD)[2]. Dosage: 20 mg/kg (also supplemented daily by the diet (200 mg/200 g powdered chow)). Administration: Subcutaneously (in 20% ethanol/80% polyethylene glycol), once a day during the entire course. Result: Lungs derived from smoking animals treated with the compound demonstrated a statistically significant reduction in the destructive lesions. Showed an increase of both pro–MMP-9 and its active form (lanes 5 to 8) as compared with control animals. |
| References |
| Molecular Formula | C16H17FN2O5S |
|---|---|
| Molecular Weight | 368.38000 |
| Exact Mass | 368.08400 |
| PSA | 116.60000 |
| LogP | 4.49230 |
| InChIKey | QCOQJYRPDUMCNP-UHFFFAOYSA-N |
| SMILES | CC(C)(NS(=O)(=O)c1ccc(Oc2ccc(F)cc2)cc1)C(=O)NO |
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Name: qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): assay vali...
Source: NCGC
External Id: adst_MBL_Abs_LOPAC_o1
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Name: Inhibitory activity against matrix metalloprotease-13 (MMP-13)
Source: ChEMBL
Target: Collagenase 3
External Id: CHEMBL717437
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Name: Extraction ratio in human liver microsomes was determined
Source: ChEMBL
Target: Homo sapiens
External Id: CHEMBL695031
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Name: Inhibition of MMP-13 induced experimental arthritis in hamster knee by 30 mg/kg p.o.
Source: ChEMBL
Target: Collagenase 3
External Id: CHEMBL694863
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|
Name: Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1315
|
|
Name: qHTS assay for measurement of the activity of small molecule inhibitors on Zika virus...
Source: NCGC
Target: N/A
External Id: ZIK097
|
|
Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582
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|
Name: Enzymatic assay of human HDAC6 with commercial peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808149
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|
Name: Enzymatic assay of human HDAC6 with custom peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808150
|
|
Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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| 2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydrox y-2-methylpropanamide PF-1626077 |
| HMS3262O11 |
| UNII-96U47H947L |