Doxofylline

Modify Date: 2025-08-21 04:41:23

Doxofylline Structure
Doxofylline structure
 Common Name Doxofylline
CAS Number 69975-86-6 Molecular Weight 266.253
Density 1.6±0.1 g/cm3 Boiling Point 505.2±53.0 °C at 760 mmHg
Molecular Formula C11H14N4O4 Melting Point 144-146ºC
MSDS USA Flash Point 259.3±30.9 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Doxofylline


Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV.

 Names

Name 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione
Synonym More Synonyms

 Doxofylline Biological Activity

Description Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV.
Related Catalog
Target

Adenosine A1 receptor, phosphodiesterase IV[1]

References

[1]. Shukla D, et al. Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease. Expert Opin Pharmacother. 2009 Oct;10(14):2343-56.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 505.2±53.0 °C at 760 mmHg
Melting Point 144-146ºC
Molecular Formula C11H14N4O4
Molecular Weight 266.253
Flash Point 259.3±30.9 °C
Exact Mass 266.101501
PSA 80.28000
LogP -0.70
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.700
InChIKey HWXIGFIVGWUZAO-UHFFFAOYSA-N
SMILES Cn1c(=O)c2c(ncn2CC2OCCO2)n(C)c1=O
Water Solubility Soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XH5135000
CHEMICAL NAME :
Theophylline, 7-(1,3-dioxolan-2-ylmethyl)-
CAS REGISTRY NUMBER :
69975-86-6
BEILSTEIN REFERENCE NO. :
0561195
LAST UPDATED :
199806
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C11-H14-N4-O4
MOLECULAR WEIGHT :
266.29
WISWESSER LINE NOTATION :
T56 BN DN FNVNVJ F1 H1 B1- BT5O COTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
965 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4868186
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
426 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4187308
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
315 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4187308
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
841 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 36,201,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
396 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4187308
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
216 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 36,201,1981

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36/37
RIDADR NONH for all modes of transport

 Articles8

More Articles
Doxofylline, an antiasthmatic drug lacking affinity for adenosine receptors.

Arch. Int. Pharmacodyn. Ther. 295 , 221-37, (1988)

In the present study the interaction of doxofylline, a new antiasthmatic drug, with A1- and A2-adenosine receptors of the guinea-pig brain and rat striatum was investigated in comparison with known me...

Doxofylline in rat brain in relation to locomotor activity.

Drug Metab. Dispos. 17(4) , 437-40, (1989)

Doxofylline is a new xanthine derivative with significant bronchodilatatory activity. We have studied in HPLC the distribution of doxofylline in various areas of rat brain (cortex, cerebellum, limbic ...

The effect of intravenous doxofylline or aminophylline on gastric secretion in duodenal ulcer patients.

Aliment. Pharmacol. Ther. 4(6) , 643-9, (1990)

The aim of this study was to compare the effects upon gastric secretion of therapeutic doses of aminophylline, with doxofylline, a new xanthine derivative proposed for the treatment of chronic asthma....

 DoxofyllineBioassay

View more

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01
Name: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
Source: NCGC
Target: N/A
External Id: SMAD3201
Name: uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay
Source: Burnham Center for Chemical Genomics
Target: cystic fibrosis transmembrane conductance regulator [Homo sapiens]
External Id: SBCCG-A764-CF-PAF-Primary-Assay
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ant...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_ANT_FLUO8_1536_1X%INH PRUN
Name: qHTS for Inhibitors of TGF-b
Source: NCGC
Target: Smad3 [Homo sapiens]
External Id: SMAD3101
Total 632, Current Page 1 of 64
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 Synonyms

Maxivent
Doxofilina [INN-Spanish]
Doxofylline
Ansimar
7-(1,3-Dioxolan-2-ylmethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
Ventax
Doxofyllinum [INN-Latin]
7-(1,3-dioxolan-2-ylmethyl)theophylline
doxophylline
EINECS 274-239-6
ABC 12/3
Dioxyfilline
2-(7'-theophyllinemethyl)-1,3-dioxolane
7-(1,3-Dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
7-(1,3-dioxolan-2-yl-methyl)3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
MFCD00865218
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Doxofylline Impurity 8
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Doxofylline Impurity 7
1429636-73-6
Doxofylline Impurity 2
1429636-74-7
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N-9H-Carbazol-3-yl-3,4-dimethylbenzamide
1170816-64-4
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1097625-14-3
Chemsrc provides Doxofylline(CAS#:69975-86-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Doxofylline are included as well.>> amp version: Doxofylline

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