Betulonic acid
Modify Date: 2026-07-01 18:00:04
Betulonic acid structure
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Common Name | Betulonic acid | ||
|---|---|---|---|---|
| CAS Number | 4481-62-3 | Molecular Weight | 454.684 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 548.1±33.0 °C at 760 mmHg | |
| Molecular Formula | C30H46O3 | Melting Point | 264 °C | |
| MSDS | N/A | Flash Point | 299.4±21.9 °C | |
Use of Betulonic acidBetulonic acid belongs to the pentacyclic triterpenic derivative class, has antitumor activities.In vitro: BEA-NP is found over three-times more permeable than that solubilized by DMSO in Caco-2 cell monocultures.[1]In vivo: The tumor growth in the S180 berry mice orally doses with BEA-NP at 75 mg/kg is inhibited by 50%. Rubusoside is effective in solubilizing BEA, maintaining its cytotoxicity, enhancing its permeability and reducing tumor growth when orally administered.[1] antitumor activities against MGC-803, PC3, Bcap-37, A375, and MCF-7 human cancer cell lines In vivo: The animals are treated with betulonic acid amide (50 mg/kg in Tween aqueous solution) and heptral (6 mg/kg) as hepatoprotective compounds. It is found that betulonic acid amide stimulats the regenerative response in hepatocytes under conditions of combined toxic exposure and promots recovery of their qualitative and quantitative characteristics. [2] |
| Name | Betulonicacid |
|---|---|
| Synonym | More Synonyms |
| Description | Betulonic acid belongs to the pentacyclic triterpenic derivative class, has antitumor activities.In vitro: BEA-NP is found over three-times more permeable than that solubilized by DMSO in Caco-2 cell monocultures.[1]In vivo: The tumor growth in the S180 berry mice orally doses with BEA-NP at 75 mg/kg is inhibited by 50%. Rubusoside is effective in solubilizing BEA, maintaining its cytotoxicity, enhancing its permeability and reducing tumor growth when orally administered.[1] antitumor activities against MGC-803, PC3, Bcap-37, A375, and MCF-7 human cancer cell lines In vivo: The animals are treated with betulonic acid amide (50 mg/kg in Tween aqueous solution) and heptral (6 mg/kg) as hepatoprotective compounds. It is found that betulonic acid amide stimulats the regenerative response in hepatocytes under conditions of combined toxic exposure and promots recovery of their qualitative and quantitative characteristics. [2] |
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| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 548.1±33.0 °C at 760 mmHg |
| Melting Point | 264 °C |
| Molecular Formula | C30H46O3 |
| Molecular Weight | 454.684 |
| Flash Point | 299.4±21.9 °C |
| Exact Mass | 454.344696 |
| PSA | 54.37000 |
| LogP | 8.36 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.527 |
| InChIKey | SLJTWDNVZKIDAU-SVAFSPIFSA-N |
| SMILES | C=C(C)C1CCC2(C(=O)O)CCC3(C)C(CCC4C5(C)CCC(=O)C(C)(C)C5CCC43C)C12 |
| Precursor 8 | |
|---|---|
| DownStream 4 | |
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