64657-21-2

64657-21-2 structure

Name: Isoforskolin
Chemical Name: Coleonol B
CAS Number: 64657-21-2
Molecular Formula: C₂₂H₃₄O₇
Molecular Weight: 410.501
Catalog: Natural product Moss
Create Date: 2018-10-17 12:20:44
Modify Date: 2024-01-06 14:11:33
Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis[1].

Name	Coleonol B
Synonyms	Isoforskolin (3R,4aR,5S,6S,10S,10aR,10bS)-5,10,10b-Trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-6-yl acetate 1H-Naphtho[2,1-b]pyran-1-one, 6-(acetyloxy)-3-ethenyldodecahydro-5,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R,4aR,5S,6S,10S,10aR,10bS)- 6-Acetyl-7-deacetylforskolin

Description	Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology
In Vitro	Isoforskolin downregulates the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA)[1].
References	[1]. Zhao H, et al. Isoforskolin downregulates proinflammatory responses induced by Borrelia burgdorferi basic membrane protein A.Exp Ther Med. 2017 Dec;14(6):5974-5980.

Hazard Codes	Xn
Risk Phrases	21
Safety Phrases	36
RIDADR	NONH for all modes of transport
WGK Germany	3

Precursor 0
DownStream 1
81873-08-7