87084-99-9

87084-99-9 structure

Name: Albanol B
Chemical Name: Albanol B
CAS Number: 87084-99-9
Molecular Formula: C₃₄H₂₂O₈
Molecular Weight: 558.53
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2017-03-23 17:48:42
Modify Date: 2024-01-03 00:01:42
Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and ERK1/2[1].

Name	Albanol B
Synonyms	(+/-)-albanol B 8aH-Benzo[3,4][2]benzopyrano[1,8-bc][1]-benzopyran-4,11-diol,8a-(2,4-dihydroxyphenyl)-6-(6-hydroxy-2-benzofuranyl)-2-methyl-,(8aR)

Description	Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and ERK1/2[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> MAPK/ERK Pathway >> ERK Research Areas >> Neurological Disease Signaling Pathways >> Stem Cell/Wnt >> ERK Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Albanol B（10 μM，30 μM；24 小时）降低 A549 细胞的细胞活力[1]。 Albanol B（30 μM；48 小时）抑制 A549 和 H1975 细胞的 G2/M 期细胞周期并诱导细胞凋亡[1]。 Albanol B（1-30 μM；1-9 小时）介导 A549 细胞中 ERK-1/2 和 AKT 的激活[1]。 Cell Viability Assay[1] Cell Line: A549 cells, BZR, NCI-H1975, and NCI-H226 cells Concentration: 0, 1, 3, 10, and 30 μM Incubation Time: 48 hours Result: Exhibited inhibitory effects on cancer cells with IC50s of 5.6 μM (A549), 8.9 μM (BZR), 12.7 μM (NCI-H1975), and 15 μM (NCI-H226), respectively. Cell Cycle Analysis[1] Cell Line: A549 and H1975 cells Concentration: 1, 3, 10 μM Incubation Time: 48 hours Result: Increased cells in G2/M phase from 9.5% to 14.34%, 18.13% and 47.9%, respectively. Western Blot Analysis[1] Cell Line: A549 cells Concentration: 1 h, 3 h, 6 h, and 9 h Incubation Time: 48 hours Result: Increased the phosphorylation levels of ERK1/2 and AKT in time- and concentration-dependent manners. Did not increase the phosphorylation level of JNK and p38 MAPKs.
In Vivo	Albanol B（50 mg/kg、100 mg/kg；腹腔注射；每天一次，持续 21 天）抑制 Ex-3LL 荷瘤小鼠的肿瘤生长[1]。 Animal Model: EX-3LL tumor-bearing mice[1] Dosage: 50 mg/kg, 100 mg/kg Administration: IP; once daily for 21 days Result: Decreased tumor volume and weight by 48.0% and 41.0% (for 50 mg/kg treatment), and 61.3% and 57.3% (for 100 mg/kg treatment), respectively.
References	[1]. Phan TN, et al. Albanol B from Mulberries Exerts Anti-Cancer Effect through Mitochondria ROS Production in Lung Cancer Cells and Suppresses In Vivo Tumor Growth. Int J Mol Sci. 2020 Dec 14;21(24):9502.

Density	1.554g/cm3
Boiling Point	828.2ºC at 760 mmHg
Molecular Formula	C₃₄H₂₂O₈
Molecular Weight	558.53
Flash Point	454.7ºC
Exact Mass	558.13100
PSA	132.75000
LogP	7.25610
Index of Refraction	1.796

89199-98-4

87084-99-9

Literature: Hano, Yoshio; Miyagawa, Yoko; Yano, Mamiko; Nomura, Taro Heterocycles, 1989 , vol. 28, # 2 p. 745 - 750

87084-99-9	105708-64-3
140852-71-7	121923-96-4
113900-78-0	105650-11-1
100046-03-5	107745-54-0
929974-17-4	132246-31-2