Albanol B
Modify Date: 2024-01-03 00:01:42
Albanol B structure
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Common Name | Albanol B | ||
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| CAS Number | 87084-99-9 | Molecular Weight | 558.53 | |
| Density | 1.554g/cm3 | Boiling Point | 828.2ºC at 760 mmHg | |
| Molecular Formula | C34H22O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 454.7ºC | |
Use of Albanol BAlbanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and ERK1/2[1]. |
| Name | Albanol B |
|---|---|
| Synonym | More Synonyms |
| Description | Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and ERK1/2[1]. |
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| Related Catalog | |
| In Vitro | Albanol B（10 μM，30 μM；24 小时）降低 A549 细胞的细胞活力[1]。 Albanol B（30 μM；48 小时）抑制 A549 和 H1975 细胞的 G2/M 期细胞周期并诱导细胞凋亡[1]。 Albanol B（1-30 μM；1-9 小时）介导 A549 细胞中 ERK-1/2 和 AKT 的激活[1]。 Cell Viability Assay[1] Cell Line: A549 cells, BZR, NCI-H1975, and NCI-H226 cells Concentration: 0, 1, 3, 10, and 30 μM Incubation Time: 48 hours Result: Exhibited inhibitory effects on cancer cells with IC50s of 5.6 μM (A549), 8.9 μM (BZR), 12.7 μM (NCI-H1975), and 15 μM (NCI-H226), respectively. Cell Cycle Analysis[1] Cell Line: A549 and H1975 cells Concentration: 1, 3, 10 μM Incubation Time: 48 hours Result: Increased cells in G2/M phase from 9.5% to 14.34%, 18.13% and 47.9%, respectively. Western Blot Analysis[1] Cell Line: A549 cells Concentration: 1 h, 3 h, 6 h, and 9 h Incubation Time: 48 hours Result: Increased the phosphorylation levels of ERK1/2 and AKT in time- and concentration-dependent manners. Did not increase the phosphorylation level of JNK and p38 MAPKs. |
| In Vivo | Albanol B（50 mg/kg、100 mg/kg；腹腔注射；每天一次，持续 21 天）抑制 Ex-3LL 荷瘤小鼠的肿瘤生长[1]。 Animal Model: EX-3LL tumor-bearing mice[1] Dosage: 50 mg/kg, 100 mg/kg Administration: IP; once daily for 21 days Result: Decreased tumor volume and weight by 48.0% and 41.0% (for 50 mg/kg treatment), and 61.3% and 57.3% (for 100 mg/kg treatment), respectively. |
| References |
| Density | 1.554g/cm3 |
|---|---|
| Boiling Point | 828.2ºC at 760 mmHg |
| Molecular Formula | C34H22O8 |
| Molecular Weight | 558.53 |
| Flash Point | 454.7ºC |
| Exact Mass | 558.13100 |
| PSA | 132.75000 |
| LogP | 7.25610 |
| Index of Refraction | 1.796 |
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Albanol B CAS#:87084-99-9 |
| Literature: Hano, Yoshio; Miyagawa, Yoko; Yano, Mamiko; Nomura, Taro Heterocycles, 1989 , vol. 28, # 2 p. 745 - 750 |
![(+)-13-(2,4-Dihydroxyphenyl)-2-(6-hydroxybenzofuran-2-yl)-6-methyl-6,12-methano-6H,12H-[1]benzopyrano[4,3-d][1]benzoxocin-4,9-diol structure](https://image.chemsrc.com/caspic/187/89199-98-4.png)
| (+/-)-albanol B |
| 8aH-Benzo[3,4][2]benzopyrano[1,8-bc][1]-benzopyran-4,11-diol,8a-(2,4-dihydroxyphenyl)-6-(6-hydroxy-2-benzofuranyl)-2-methyl-,(8aR) |