935467-97-3

935467-97-3 structure

Name: TH-237A
Chemical Name: 1H,3H,5H-Oxazolo[3,4-c]oxazole-7a(7H)-methanol, 3,5-bis(4-fluorophenyl)-, (3R,5S)-rel
CAS Number: 935467-97-3
Molecular Formula: C₁₈H₁₇F₂NO₃
Molecular Weight: 333.329
Catalog: Research Areas Neurological Disease
Create Date: 2018-08-31 19:20:31
Modify Date: 2024-01-11 21:12:21
TH-237A(meso-GS 164) is a novel neuroprotective agent exhibiting favorable permeation across the blood brain barrier.IC50 value: 5 nM (EC50, concentration that leads to a 50% increase in neuronal survival in the presence of the Aβ peptides)Target: Primary neurons were isolated from embryonic Sprague-Dawley rats, grown in culture (Michaelis et al., 1994) and exposed to either Aβ25-35 or Aβ1-42 in the presence or absence of TH-237A at concentrations ranging from 0.5 to 60 nM. The neurons were treated with TH-237A for 2 hours prior to exposure to the Aβ peptides. Changes in neuronal survival following treatment with TH 237A were evaluated using the Live/Dead assay. The EC50 for TH-237A was 5 nM, demonstrating that it had excellent neuroprotective properties.

Name	1H,3H,5H-Oxazolo[3,4-c]oxazole-7a(7H)-methanol, 3,5-bis(4-fluorophenyl)-, (3R,5S)-rel
Synonyms	TH 237A [(3R,5S)-3,5-Bis(4-fluorophenyl)-1H-[1,3]oxazolo[3,4-c][1,3]oxazol-7a(7H)-yl]methanol (3R,5S,7as)-[3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl]methanol 1H,3H,5H-Oxazolo[3,4-c]oxazole-7a(7H)-methanol, 3,5-bis(4-fluorophenyl)-, (3R,5S)- meso-GS 164 TH-237A

Description	TH-237A(meso-GS 164) is a novel neuroprotective agent exhibiting favorable permeation across the blood brain barrier.IC50 value: 5 nM (EC50, concentration that leads to a 50% increase in neuronal survival in the presence of the Aβ peptides)Target: Primary neurons were isolated from embryonic Sprague-Dawley rats, grown in culture (Michaelis et al., 1994) and exposed to either Aβ25-35 or Aβ1-42 in the presence or absence of TH-237A at concentrations ranging from 0.5 to 60 nM. The neurons were treated with TH-237A for 2 hours prior to exposure to the Aβ peptides. Changes in neuronal survival following treatment with TH 237A were evaluated using the Live/Dead assay. The EC50 for TH-237A was 5 nM, demonstrating that it had excellent neuroprotective properties.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Kelly E. Desino, Improving Blood Brain Barrier Permeation of Small Molecules Exhibiting Chemotherapeutic and Neuroprotective Effects.