2244678-29-1

2244678-29-1 structure

Name: TH 257
Chemical Name: TH-257
CAS Number: 2244678-29-1
Molecular Formula: C₂₄H₂₆N₂O₃S
Molecular Weight: 422.54
Catalog: Research Areas Cancer
Create Date: 2019-12-08 21:39:32
Modify Date: 2024-01-11 13:52:14
TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM for LIMK1 and LIMK2, respectively, and it can be used as a chemical probe for LIMK1 and LIMK2. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM[1].

Name	TH-257

Description	TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM for LIMK1 and LIMK2, respectively, and it can be used as a chemical probe for LIMK1 and LIMK2. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM[1].
Related Catalog	Research Areas >> Cancer
Target	LIMK1:84 nM (IC50) LIMK2:39 nM (IC50)
References	[1]. Manetti F. Recent advances in the rational design and development of LIM kinase inhibitors are not enough to enter clinical trials. Eur J Med Chem. 2018 Jul 15;155:445-458.

Molecular Formula	C₂₄H₂₆N₂O₃S
Molecular Weight	422.54

Hazard Codes	Xi