BioBioPha
China
Product Name: 3-Nitropropanoic acid
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Propanoic acid,3-nitro-
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Zhejiang Hangyu API Co., Ltd
China
Product Name: 3-NITROPROPIONIC ACID
Price: ￥Inquiry/1kg
Purity: 99.5%
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Contact: Vinnie

504-88-1

504-88-1 structure

Name: 3-Nitropropanoic acid
Chemical Name: 3-nitropropanoic acid
CAS Number: 504-88-1
Molecular Formula: C₃H₅NO₄
Molecular Weight: 119.076
Catalog: Chemical reagent Organic reagent fatty acid
Create Date: 2018-05-30 08:00:00
Modify Date: 2024-01-02 19:37:48
3-Nitropropanoic acid is an irreversible inhibitor of succinate dehydrogenase.

Name	3-nitropropanoic acid
Synonyms	Propanoic acid, 3-nitro- (9CI) Propanoic acid,3-nitro Propanoic acid, 3-nitro- Hiptagenic acid 3-Nitropropionate Propionic acid,3-nitro Bovinocidin 3-nitro propionic acid RN 1 dihydrochloride β-Nitropropionic acid 3-Nitropropionic acid propionic acid, 3-nitro- 3-Nitropropanoic acid β-Nitropropanoic acid

Description	3-Nitropropanoic acid is an irreversible inhibitor of succinate dehydrogenase.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	succinate dehydrogenase[1]
References	[1]. Huang LS, et al. 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J Biol Chem. 2006 Mar 3;281(9):5965-72.

Density	1.4±0.1 g/cm3
Boiling Point	303.0±25.0 °C at 760 mmHg
Melting Point	68-70ºC(lit.)
Molecular Formula	C₃H₅NO₄
Molecular Weight	119.076
Flash Point	148.4±11.6 °C
Exact Mass	119.021858
PSA	83.12000
LogP	-0.08
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.463
Stability	Stable. Incompatible with strong oxidizing agents, bases, reducing agents.
Water Solubility	alcohol: 100 mg/mL, may be light yellow

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UF6220000

CHEMICAL NAME :: Propionic acid, 3-nitro-

CAS REGISTRY NUMBER :: 504-88-1

BEILSTEIN REFERENCE NO. :: 1759889

LAST UPDATED :: 199706

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C3-H5-N-O4

MOLECULAR WEIGHT :: 119.09

WISWESSER LINE NOTATION :: WN2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 67 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 68100 ug/kg

TOXIC EFFECTS :: Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1870 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: Specific locus test

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 50 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 196,61,1988

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	Missing Phrase - N15.00950417
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T
Risk Phrases	25-36/37/38
Safety Phrases	26-45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	UF6220000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2915900090

58657-26-4

~96%

504-88-1

Literature: COUNCIL OF SCIENTIFIC and INDUSTRIAL RESEARCH; Kamal, Ahmed; Murty, Jayanti Naga Srirama Chandra; Viswanath, Arutla Patent: US2013/317211 A1, 2013 ; Location in patent: Paragraph 0271 ;

930-21-2

~98%

504-88-1

Literature: Annese, Cosimo; D'Accolti, Lucia; Filardi, Rosella; Tommasi, Immacolata; Fusco, Caterina Tetrahedron Letters, 2013 , vol. 54, # 6 p. 515 - 517

802294-64-0

504-88-1

Literature: Hass; Hudgin Journal of the American Chemical Society, 1954 , vol. 76, p. 2692

590-92-1

~72%

504-88-1

Literature: Addo, James K.; Teesdale-Spittle, Paul; Hoberg, John O. Synthesis, 2005 , # 12 art. no. M09404SS, p. 1923 - 1925

57-57-8

504-88-1

Literature: Gresham et al. Journal of the American Chemical Society, 1952 , vol. 74, p. 1323 Full Text View citing articles Show Details Hass et al. Journal of the American Chemical Society, 1951 , vol. 73, p. 1858

141-76-4

504-88-1

Literature: Lewkowitsch Journal fuer Praktische Chemie (Leipzig), 1879 , vol. <2>20, p. 169

7697-37-2

802294-64-0

504-88-1

Literature: Hass; Hudgin Journal of the American Chemical Society, 1954 , vol. 76, p. 2692

Precursor 6
58657-26-4 930-21-2 590-92-1 57-57-8
141-76-4 7697-37-2
DownStream 7
20497-95-4 3590-37-2 690-39-1 107-95-9
25182-84-7 75640-08-3 51834-15-2

HS Code	2915900090
Summary	2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

504-88-1	36629-54-6
20497-95-4	74612-10-5
82588-80-5	63819-85-2
824956-49-2	1104636-71-6
39193-98-1	91681-56-0