68414-18-6

68414-18-6 structure

Name: Adenosine 5′-diphosphoribose sodium
Chemical Name: [[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] (2,3,4-trihydroxy-5-oxopentyl) hydrogen phosphate,sodium
CAS Number: 68414-18-6
Molecular Formula: C₁₅H₂₂N₅NaO₁₄P₂
Molecular Weight: 581.29800
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-07-09 12:24:20
Modify Date: 2024-01-06 19:43:49
Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy[1][2].

Name	[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] (2,3,4-trihydroxy-5-oxopentyl) hydrogen phosphate,sodium
Synonyms	Adenosine 5'-diphosphoribose sodium salt Adenosine 5 inverted exclamation marka-diphosphoribose sodium salt MFCD00136017

Description	Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Endocrinology Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Metabolic Disease
Target	TRPM2 channel[1][2] Autophagy[1]
In Vitro	In mouse embryonic fibroblasts (MEFs), H2O2 treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca2+ elevation through extracellular Ca2+ influx and (or) lysosomal Ca2+ release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress[1][1]. TRPM2 channels are activated by binding of Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca2+ is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands[2].
References	[1]. Zhang DX, et al. The potential regulatory roles of NAD(+) and its metabolism in autophagy. Metabolism. 2016 Apr;65(4):454-62. [2]. Tóth B, et al. Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13440-5.

Molecular Formula	C₁₅H₂₂N₅NaO₁₄P₂
Molecular Weight	581.29800
Exact Mass	581.05400
PSA	313.97000
Storage condition	-20°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26;S36
RIDADR	NONH for all modes of transport

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