Shanghai Nianxing Industrial Co., Ltd
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Product Name: Adenosine 5′-monophosphate disodium salt
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Shanghai Jizhi Biochemical Technology Co., Ltd
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Product Name: Adenosine 5′-monophosphate disodium salt
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Dayang Chem (Hangzhou) Co., Ltd.
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Sodium ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate
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Taiwan Oyi peptide Co. Ltd
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Product Name: Adenosine 5'-monophosphate disodium salt
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4578-31-8

4578-31-8 structure

Name: Adenosine 5′-monophosphate disodium salt
Chemical Name: Sodium ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate
CAS Number: 4578-31-8
Molecular Formula: C₁₀H₁₂N₅Na₂O₇P
Molecular Weight: 391.185
Catalog: Biochemical Nucleoside drugs Nucleotides and their analogues
Create Date: 2018-09-07 08:06:34
Modify Date: 2024-01-02 12:25:52
Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes[1][2][3].

Name	Sodium ((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate
Synonyms	Disodium 5'-O-phosphonatoadenosine Disodium adenosine 5'-phosphate Adenosine 5'-monophosphate disodium salt MFCD00065023 Adenosine-5'-monophosphate disodium salt Dinatrium-9-(5-O-phosphonato-β-D-ribofuranosyl)-9H-purin-6-amin Adenosine 5′-monophosphate sodium salt AMP disodium salt EINECS 224-961-2 5'-Adenylic acid, sodium salt (1:2) 5'-AMP-Na2 Adenosine 5’-Monophosphate Disodium Salt 5′-AMP-Na2 Disodium [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydro-2-furanyl]methyl phosphate

Description	Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes[1][2][3].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	A2BR
In Vivo	Adenosine 5'-monophosphate (10 和 13 mg/L，添加在蒸馏水中，25 周) disodium 改善 HFD 诱导的糖尿病小鼠的葡萄糖代谢[1]。 Adenosine 5'-monophosphate (40-800 mg/kg，i.p.) disodium 通过小鼠体内的腺苷受体降低体温[2]。 Animal Model: C57BL/6 J mice with high-fat diet-induced diabetes[1] Dosage: 10 and 13 mg/L Administration: Added in distilled water, for 25 weeks Result: Enhanced phosphorylation of AMPK and mRNA levels of genes involved in lipid oxidation in the skeletal muscle.
References	[1]. Ardiansyah, et al. Adenosine and adenosine-5'-monophosphate ingestion ameliorates abnormal glucose metabolism in mice fed a high-fat diet. BMC Complement Altern Med. 2018 Nov 14;18(1):304. [2]. Steven J. Swoap, et al. AMP does not induce torpor. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2007 293:1, R468-R473. [3]. Holien JK, et al. AMP and adenosine are both ligands for adenosine 2B receptor signaling. Bioorg Med Chem Lett. 2018 Jan 15;28(2):202-206.

Boiling Point	798.5ºC at 760 mmHg
Melting Point	232-235ºC
Molecular Formula	C₁₀H₁₂N₅Na₂O₇P
Molecular Weight	391.185
Flash Point	436.7ºC
Exact Mass	391.026978
PSA	201.54000
Storage condition	−20°C
Water Solubility	H2O: soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7481600

CHEMICAL NAME :: 5'-Adenylic acid, disodium salt

CAS REGISTRY NUMBER :: 4578-31-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H12-N5-O7-P.2Na

MOLECULAR WEIGHT :: 391.22

WISWESSER LINE NOTATION :: T56 BM DN FN HNJ IZ D- BT5OTJ CQ DQ E1OPO&O&O &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 830 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 33,24,1974

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AU7481600

58-61-7

4578-31-8

Literature: Barai, Vladimir N.; Zinchenko, Anatoli I.; Kvach, Sergei V.; Titovich, Olga I.; Rubinova, Elena B.; Kalinichenko, Elena N.; Mikhailopulo, Igor A. Helvetica Chimica Acta, 2003 , vol. 86, # 8 p. 2827 - 2832

Precursor 1
58-61-7
DownStream 3
108321-99-9 61-19-8 3387-36-8

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