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60-01-5 557-25-5
7682-14-6

60-01-5

60-01-5 structure
60-01-5 structure
  • Name: butyrin
  • Chemical Name: tributyrin
  • CAS Number: 60-01-5
  • Molecular Formula: C15H26O6
  • Molecular Weight: 302.363
  • Catalog: Flavors and spices Synthetic spice Carboxylic acid and ester perfume Aliphatic carboxylate
  • Create Date: 2018-09-09 10:44:01
  • Modify Date: 2024-01-02 10:40:21
  • Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed prodrug of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing effective butyrate directly into the cell in vivo. Tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects[1].
Name tributyrin
Synonyms Tributyrinine
MFCD00009392
1,2,3-Propanetriyl tributanoate
Butanoic acid, 1,2,3-propanetriyl ester
Propane-1,2,3-triyl tributanoate
Tributyroin
glyceryl tributyrate
Tributin
Butyryl triglyceride
Glycerol tributyrate
2,3-di(butanoyloxy)propyl butanoate
EINECS 200-451-5
glycerol tributanoate
1,2,3-Tributyrylglycerol
Butanoic acid,1,2,3-propanetriyl ester
butyrin
TRIBUTYRIN
Description Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed prodrug of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing effective butyrate directly into the cell in vivo. Tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects[1].
Related Catalog
References

[1]. T Gaschott, et al. Tributyrin, a stable and rapidly absorbed prodrug of butyric acid, enhances antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells. J Nutr. 2001 Jun;131(6):1839-43.

[2]. Claudia P Schröder, et al. Tributyrin-induced differentiation promotes apoptosis of LS 174T colon cancer cells in vitro. Int J Oncol. 2002 Jan;20(1):195-200.
Density 1.1±0.1 g/cm3
Boiling Point 307.5±0.0 °C at 760 mmHg
Melting Point -75 °C
Molecular Formula C15H26O6
Molecular Weight 302.363
Flash Point 173.9±0.0 °C
Exact Mass 302.172943
PSA 78.90000
LogP 2.95
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.448
Storage condition Store at RT.
Stability Stable. Incompatible with strong oxidizing agents.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ET7350000
CHEMICAL NAME :
Butyrin, tri-
CAS REGISTRY NUMBER :
60-01-5
BEILSTEIN REFERENCE NO. :
1714746
LAST UPDATED :
199707
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C15-H26-O6
MOLECULAR WEIGHT :
302.41
WISWESSER LINE NOTATION :
3VO1YOV3&1OV3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
TYPE OF TEST :
LC - Lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>75 ppm/6H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
APSCAX Acta Physiologica Scandinavica. (Karolinska Institutet, S-10401 Stockholm, Sweden) V.1- 1940- Volume(issue)/page/year: 40,338,1957 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
177 gm/kg/3W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 10,361,1949
Personal Protective Equipment Eyeshields;Gloves
Hazard Codes Xi
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS ET7350000
HS Code 2915900090
56-81-5 structure

56-81-5
107-92-6 structure

107-92-6

~92%

60-01-5 structure

60-01-5
Literature: Prager, Rolf H.; Yurui, Zhang Australian Journal of Chemistry, 1989 , vol. 42, # 6 p. 1003 - 1005
106-31-0 structure

106-31-0
144-55-8 structure

144-55-8

~95%

60-01-5 structure

60-01-5
Literature: Akthelia Pharmaceuticals Patent: US2011/118217 A1, 2011 ;
106-31-0 structure

106-31-0
56-81-5 structure

56-81-5

~%

60-01-5 structure

60-01-5
Literature: Nudelman, Abraham; Ruse, Margaretta; Aviram, Adina; Rabizadeh, Ester; Shaklai, Matityahu; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 687 - 694
156-54-7 structure

156-54-7
56-81-5 structure

56-81-5

~%

60-01-5 structure

60-01-5
Literature: Newman; Trikojus; Harker Journal and Proceedings of the Royal Society of New South Wales, vol. 59, p. 296 Chem. Zentralbl., 1927 , vol. 98, # II p. 802
96-11-7 structure

96-11-7
5076-24-4 structure

5076-24-4

~%

60-01-5 structure

60-01-5
Literature: Partheil; v.Velsen Archiv der Pharmazie (Weinheim, Germany), 1900 , vol. 238, p. 267
107-92-6 structure

107-92-6

~%

60-01-5 structure

60-01-5
Literature: Newman; Trikojus; Harker Journal and Proceedings of the Royal Society of New South Wales, vol. 59, p. 298 Chem. Zentralbl., 1927 , vol. 98, # II p. 802
96-11-7 structure

96-11-7
156-54-7 structure

156-54-7

~%

60-01-5 structure

60-01-5
Literature: Guth Z.B., 1903 , vol. 44, p. 95
HS Code 2915900090
Summary 2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

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